补肾利湿化瘀汤联合左氧氟沙星治疗慢性前列腺炎的临床疗效分析

Analysis of clinical efficacy of Bushen Lishi Huayu decoction combined with levofloxacin on chronic prostatitis

目的:探究补肾利湿化瘀汤与左氧氟沙星联合治疗对慢性前列腺炎的临床疗效。方法:以随机数字表法将2020年3月―2022年3月我院收治的80例慢性前列腺炎患者分为两组,对照组给予左氧氟沙星治疗,观察组给予补肾利湿化瘀汤与左氧氟沙星联合治疗。比较两组临床疗效,慢性前列腺炎症状评分表(NIH-CPSI)评价前列腺炎症状严重程度,并比较两组患者治疗前后排尿功能、精液常规指标及炎性因子水平、免疫功能指标。结果:观察组治疗总有效率为92.50%,显著高于对照组75.00%;观察组治疗后NIH-CPSI评分及最大尿流率、平均尿流率分别为(10.62±1.91)分、(21.58±2.92)mL/s、(12.91±0.86)mL/s,均高于对照组[分别为(14.35±1.74)分、(19.06±2.30)mL/s、(12.47±0.81)mL/s],治疗后血清及前列腺液γ-干扰素(IFN-γ)、肿瘤坏死因子-α(TNF-α)水平分别为(22.39±4.24)mg/L、(28.31±5.18)mg/L、(95.06±9.31)mg/L和(80.31±8.09)mg/L,均低于对照组[分别为(25.16±3.95)mg/L、(32.59±5.02)mg/L、(110.34±9.85)mg/L和(91.62±8.24)mg/L];观察组治疗后精子液化时间为(27.62±3.41)min,短于对照组[(29.13±3.06)min];观察组治疗后CD4^(+)/CD8^(+)值为(1.52±0.12)大于对照组[(1.39±0.15)];两组治疗期间均未出现不良反应。结论:补肾利湿化瘀汤联合左氧氟沙星治疗慢性前列腺炎的有效率高,可减轻前列腺炎症状,降低机体炎性因子水平,并能改善排尿功能及免疫功能。

Objective To explore the clinical efficacy of Bushen Lishi Huayu decoction combined with levofloxacin in the treatment of chronic prostatitis.Methods 80 patients with chronic prostatitis from March 2020 to March 2022 were divided into two group by random number table method.The control group was given levofloxacin treatment,and the observation group was given Bushen Lishi Huayu decoction The clinical efficacy was compared between the two groups.The severity of prostatitis inflammation was evaluated by National Institutes of NIH-CPSI,and the urination function,semen routine indexes,inflammatory factors and immune function indexes were compared.Results The total effective rate of treatment in observation group was higher than that in control group(92.50%vs 75.00%).The NIH-CPSI score,maximum urine flow rate,average urine flow rate and CD4^(+)/CD8^(+)in observation group after treatment were higher than those in control group[(10.62±1.91)scores,(21.58±2.92)mL/s,(12.91±0.86)mL/s,(1.52±0.12)vs(14.35±1.74)scores,(19.06±2.30)mL/s,(12.47±0.81)mL/s,(1.39±0.15)],while the levels of interferon-γ(IFN-γ)and tumor necrosis faction-α(TNF-α)in serum and prostatic fluid after treatment were lower than those in control group[(22.39±4.24)mg/L,(28.31±5.18)mg/L,(95.06±9.31)mg/L and(80.31±8.09)mg/L vs(25.16±3.95)mg/L,(32.59±5.02)mg/L,(110.34±9.85)mg/L and(91.62±8.24)mg/L].The sperm liquefaction time in observation group after treatment was shorter than that in control group[(27.62±3.41)min vs(29.13±3.06)min].There were no adverse reactions in both groups during treatment.Conclusion Bushen Lishi Huayu decoction combined with levofloxacin has high effective rate in the treatment of chronic prostatitis.It can relieve the prostatitis symptoms,reduce the levels of body's inflammatory factors,and improve the urination function and immune function.