西那卡塞联合氯雷他定治疗维持性血液透析患者皮肤瘙痒的临床疗效观察

Clinical observation on the efficacy of cinacalcet combined with Loratadine in treating skin pruritus in maintenance hemodialysis patients

目的 :观察西那卡塞联合氯雷他定治疗维持性血液透析(MHD)患者皮肤瘙痒的临床疗效。方法 :选取2020年8月―2021年8月在本院血液净化中心规律行血液透析并发皮肤瘙痒患者80例,随机分为对照组和观察组,每组40例。对照组给予氯雷他定治疗,观察组患者在对照组基础上联合西那卡塞治疗。连续治疗3个月后,比较两组患者血清因子(BUN、Scr)、临床疗效、视觉模拟评分(VAS)、改良Duo氏瘙痒评分、匹兹堡睡眠质量指数问卷评分(PSQI)及不良反应发生情况。结果 :治疗前后两组患者血清BUN、Scr无明显差异;观察组患者临床疗效显著优于对照组;观察组患者VAS评分、改良Duo氏瘙痒评分及PSQI评分较对照组显著降低。结论 :西那卡塞联合氯雷他定治疗MHD患者皮肤瘙痒疗效显著,可有效缓解MHD患者的皮肤瘙痒症状,同时改善患者的生活及睡眠质量,值得临床推广。

Objective To observe the clinical efficacy of cinacalcet combined with loratadine in the treatment of skin pruritus in maintenance hemodialysis(MHD)patients.Methods 80 patients with regular hemodialysis and skin pruritus in our hospital’s blood purification center from August 2020 to August 2021 were selected and randomly divided into a control group and an observation group,with 40 cases in each group.The control group was treated with loratadine,while the observation group was treated with cinacalcet combined with loratadine on the basis of the control group.After 3 months of continuous treatment,serum factors(BUN,Scr),clinical efficacy,visual analogue score(VAS),modified Duo itch score,Pittsburgh Sleep Quality Index questionnaire score(PSQI)and adverse reactions were compared between the two groups.Results Compared with before treatment,there was no significant difference in serum BUN and Scr between the two groups after treatment.The clinical efficacy of the observation group was significantly better than that of the control group,with a statistically significant difference.The VAS score,modified Duo itch score and PSQI score of patients in the observation group were significantly lower than those in the control group.Conclusion Cinacalcet combined with loratadine has a significant effect on MHD skin pruritus and can effectively relieve skin pruritus symptoms in MHD patients while improving their quality of life and sleep quality.It is worth promoting clinically.