清宫止带汤联合利普刀对重度宫颈糜烂血清炎症因子、微循环及HPV的影响

Effect of Qinggong Zhidai decoction combined with LEEP on inflammatory factors,microcirculation and HPV in severe cervical erosion

目的 :探讨清宫止带汤联合利普刀(Leep)治疗重度宫颈糜烂湿热下注证的临床效果。方法 :选取2020年7月―2022年3月本院收治的重度宫颈糜烂湿热下注证患者200例作为研究对象。以随机数字表法将研究对象纳入观察组(100例),对照组(100例)。两组患者均给予Leep手术治疗。对照组术后口服甲硝唑进行治疗,观察组口服清宫止带汤治疗,疗程14 d。治疗前后,比较两组炎症因子水平及中医症状积分;比较两组宫颈局部微循环、HPV-DNA清除、不良反应发生情况。结果 :治疗后,观察组白细胞介素-1(IL-1)、白细胞介素-2(IL-2)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)均显著低于对照组;观察组分泌物异常等主症评分、烦躁易怒等次症评分及症状总分均低于对照组;观察组局部血流灌注、毛细血管管径、微血管管径均明显高于对照组;观察组HPV-DNA 16、HPV-DNA 18相对表达量均低于对照组。治疗后,观察组外阴灼热、坠胀、腹痛发生率及不良反应总发生率与对照组比较,差异无显著性。结论 :清宫止带汤联合Leep刀对重度宫颈糜烂湿热下注证具有较好疗效,可显著降低其炎症水平,缓解临床症状,改善宫颈局部微循环,清除HPV,且不增加不良反应发生率。

Objective To investigate the efficacy of Qinggong Zhidai decoction combined with LEEP in the treatment of damp heat injection syndrome of severe cervical erosion and its effect on inflammatory factors.Methods 200 patients with severe cervical erosion damp heat injection syndrome treated in our hospital from July 2020 to March2022 were selected as the research object.The subjects were randomly divided into observation group and control group,each group 100 cases.Both groups were treated with LEEP operation.The control group treated with metronidazole file after operation,and the observation group treated with Qinggong Zhidai decoction.Before and after treatment,the levels of inflammatory factors and TCM symptom scores were compared.After treatment,the clinical efficacy and adverse reactions of the two groups were compared.Results After treatment,the levels of interleukin-1(IL-1),interleukin-2(IL-2),interleukin-6(IL-6)and tumor necrosis factor(TNF)in the observation group were significantly lower than those in the control group;After treatment,the scores of main symptoms such as abnormal secretion,secondary symptoms such as irritability and total symptoms in the observation group were lower than those in the control group.After treatment,the local blood flow perfusion,capillary diameter and microvascular diameter in the observation group were greater than those in the control group.After treatment,the relative expressions of HPV-DNA 16 and HPV-DNA 18 in the observation group were lower than those in the control group.At the same time,there was no significant difference between the observation group and the control group.Conclusion Qinggong Zhidai decoction combined with Leep knife has a good effect on severe cervical erosion damp-heat syndrome,which can significantly reduce the level of inflammation,alleviate clinical symptoms,improve local cervical microcirculation,remove HPV,and does not increase the incidence of adverse reactions.