肺热清颗粒联用糖皮质激素对小儿支气管哮喘氧化/抗氧化失衡的影响

Effect of Feireqing Granules Combined with Glucocorticoids on Oxidation/Antioxidation Imbalance in Children with Bronchial Asthma

目的:研究肺热清颗粒联用糖皮质激素对小儿支气管哮喘氧化/抗氧化失衡的影响。方法:选取我院124例支气管哮喘患儿,数字表法随机分为对照组(n=62)和观察组(n=62)。对照组行常规布地奈德治疗,观察组在此基础上联合肺热清颗粒治疗。比较两组临床疗效及临床体征,对比两组治疗前后肺功能[第一秒最大呼气容积(FEV1)、第1 s用力呼气容积占用力肺活量的比值(FEV1/FVC%)、最大呼气流量(PEF)]及氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)、过氧化物酶(GSH-Px)]变化,观察两组不良反应发生率。结果:观察组总有效率为95.16%,高于对照组的83.88%。观察组咳嗽、咳痰、喘息及发热消失时间均短于对照组。两组治疗后FEV1、FEV1/FVC、PEF水平均较治疗前升高;观察组治疗后FEV1、FEV1/FVC、PEF水平高于对照组。两组治疗后SOD、GSH-Px水平较治疗前升高,MOD水平较治疗前降低;观察组治疗后SOD、GSH-Px水平高于对照组,MOD水平低于对照组。观察组不良反应发生率为8.06%,较对照组的4.84%比较差异无统计学意义。结论:肺热清颗粒联合糖皮质激素可提高支气管哮喘患儿临床疗效,有助于促进肺功能恢复,纠正氧化/抗氧化失衡情况,值得推广。

Objective To study the effect of Feireqing granule combined with glucocorticoid on oxidation/antioxidation imbalance in children with bronchial asthma.Methods 124 children with bronchial asthma in our hospital were randomly divided into control group(n=62)and observation group(n=62).The control group received conventional budesonide treatment,and the observation group was treated with Feireqing granules on this basis.Compare the clinical efficacy and clinical signs of the two groups,compare the lung function[maximum expiratory volume in the first second(FEV1),The ratio of the forced expiratory volume to the forced vital capacity in the first s(FEV1/FVC%),maximum expiratory flow(PEF)]and oxidative stress indicators before and after treatment.[Malondialdehyde(MDA),superoxide dismutase(SOD),peroxidase(GSH-Px)]changes,observe the incidence of adverse reactions in the two groups.Results The total effective rate of the observation group was 95.16%,which was higher than 83.88%of the control group.The disappearance time of cough,sputum,wheezing and fever in the observation group was shorter than that in the control group.After treatment,the levels of FEV1,FEV1/FVC,and PEF in the two groups were higher than those before treatment;the levels of FEV1,FEV1/FVC,and PEF in the observation group after treatment were higher than those in the control group.After treatment,the levels of SOD and GSH-Px in the two groups were higher than before treatment,and the levels of MOD were lower than before treatment;the levels of SOD and GSH-Px in the observation group were higher than those in the control group after treatment,the MOD level was lower than the control group.The incidence of adverse reactions in the observation group was 8.06%,which was not statistically different from 4.84%in the control group.Conclusion Feireqing granules combined with glucocorticoids can improve the clinical efficacy of bronchial asthma in children,help to promote the recovery of lung function,and correct the oxidation/antioxidation imbalance.It is worthy of promotion.