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生长抑素联合乳酸菌治疗急性胰腺炎的疗效及对肠道黏膜屏障功能影响探讨 被引量:8

Effect of somatostatin combined with lactic acid bacteria in the treatment of acute pancreatitis and its influence on intestinal mucosal barrier function
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摘要 目的:探讨生长抑素联合乳酸菌治疗急性胰腺炎的疗效及对肠道黏膜屏障功能的影响。方法:选取我院收治的急性胰腺炎患者116例,随机分为研究组(58例,常规治疗+生长抑素治疗)与对照组(58例,常规治疗+生长抑素+乳酸菌治疗)。比较两组患者治疗前后临床症状改善时间、疗效、血清炎性因子水平、肠道黏膜屏障功能指标水平。结果:与对照组比较,研究组腹痛腹胀缓解时间、血清淀粉酶恢复正常时间、排气排便恢复正常时间、住院时间均更短。研究组治疗总有效率为93.10%(54/58),高于对照组的治疗总有效率77.59%(45/58)。与治疗前比较,治疗后两组血清IL-6、IL-8、TNF-α水平均降低,且研究组低于对照组。与治疗前比较,治疗后两组血清D-乳酸、DAO、ET水平均降低,且研究组低于对照组。结论:生长抑素联合乳酸菌治疗急性胰腺炎疗效显著,可有效改善患者临床症状,降低炎症因子水平,改善肠道黏膜屏障功能。 Objective To investigate the effect of somatostatin combined with lactic acid bacteria in the treatment of acute pancreatitis and its influence on the intestinal mucosal barrier function.Methods 116 patients with acute pancreatitis in our hospital were selected and randomly divided into a study group(58 cases,conventional treatment+somatostatin treatment)and a control group(58 cases,conventional treatment+somatostatin+lactic acid bacteria treatment).The clinical symptoms improvement time,curative effect,serum inflammatory factor levels,and intestinal mucosal barrier function index levels were compared between the two groups of patients before and after treatment.Results Compared with the control group,the study group had shorter time to relieve abdominal pain and bloating,time to return to normal serum amylase,time to return to normal airflow and defecation,and shorter hospital stay.The total effective rate of treatment in the study group was 93.10%(54/58),which was higher than the total effective rate of 77.59%(45/58)in the control group.Compared with before treatment,the levels of serum IL-6,IL-8 and TNF-αin the two groups decreased after treatment,and the study group was lower than the control group.Compared with before treatment,the levels of serum D-lactic acid,DAO and ET in the two groups decreased after treatment,and the study group was lower than the control group.Conclusion Somatostatin combined with lactic acid bacteria is effective in treating acute pancreatitis,which can effectively improve the clinical symptoms of patients,reduce the level of inflammatory factors,and improve the intestinal mucosal barrier function.
作者 刘大铮 张仪 刘海防 Liu Da-zheng;Zhang Yi;Liu Hai-fang(Department of Gastroenterology,Huaibei Miners General Hospital,Huaibei 235000,China)
出处 《湖南师范大学学报(医学版)》 2021年第4期208-211,共4页 Journal of Hunan Normal University(Medical Sciences)
关键词 急性胰腺炎 生长抑素 乳酸菌 白细胞介素 D-乳酸 内毒素 acute pancreatitis somatostatin lactic acid bacteria interleukin d-lactic acid endotoxin
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