急性脑梗死患者Hp感染与Hcy、FIB及APTT的相关性分析

Correlation of Hp infection with Hcy,FIB and APTT in patients with acute cerebral infarction

目的:探讨急性脑梗死患者血清同型半胱氨酸(Hcy)、纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)水平与幽门螺旋杆菌(Hp)感染的相关性。方法:回顾分析了2016年10月~2019年10月医院收治80例急性脑梗死患者的临床资料作为疾病组,另外选取同期体检的80例健康人作为对照组。比较两组Hp感染情况,根据Hp感染检查结果将疾病组分为Hp感染组和非感染组,比较两个亚组血清Hcy、FIB、APTT水平,ROC曲线评估血清Hcy、FIB、APTT水平与急性脑梗死患者并发Hp感染的关系。结果:疾病组中Hp感染率为78.75%(63/80),健康组中Hp感染率为41.25%(33/80),两组Hp感染率比较,差异有统计学意义。疾病组血清Hcy、FIB均高于健康组;两组APTT水平比较,差异无统计学意义。根据Hp感染检查结果,将疾病组分为Hp感染组(n=63)和未感染组(n=17)。Hp感染组血清Hcy、FIB均高于未感染组,APTT低于未感染组。ROC曲线分析显示,血清Hcy、FIB、APTT分别预测急性脑梗死患者并发Hp感染的曲线下面积(AUC)为0.784、0.766、0.685,低于三者联合检测AUC 0.841。结论:急性脑梗死患者的Hp感染率高于正常人,急性脑梗死患者血清Hcy和FIB水平升高、APTT的缩短与Hp感染有一定的联系。

Objective To explore correlation between serum homocysteine(Hcy),fibrinogen(FIB),activated partial thromboplastin time(APTT)levels and Helicobacter pylori(Hp)infection in patients with acute cerebral infarction(ACI).Methods The clinical data of 80 ACI patients who were admitted to the hospital from October 2016 to October 2019 were retrospectively analyzed(disease group).Another 80 healthy people who underwent physical examination during the same period were enrolled as healthy group.Hp infection situations were compared between the two groups.According to examination results of the Hp infection,disease group was divided into Hp infection group and Hp non-infection group.The levels of serum Hcy,FIB and APTT were compared between the two subgroups.Relationship between Hp infection and levels of serum Hcy,FIB and APTT in ACI patients was evaluated by ROC curves.Results There was significant difference in Hp infection rate between disease group and healthy group[78.75%(63/80)vs 41.25%(33/80)].The serum Hcy and FIB in disease group were higher than those in healthy group.There was no significant difference in APTT level between the two groups.According to examination results of Hp infection,disease group was divided into Hp infection group(n=63)and Hp non-infection group(n=17).The serum Hcy and FIB in Hp infection group were higher than those in Hp non-infection group,while APTT was lower than that in Hp non-infection group.ROC curve analysis showed that areas under the curve(AUC)of serum Hcy,FIB and APTT for predicting Hp infection in ACI patients were 0.784,0.766 and 0.685,which was lower than that of combined detection with the three(0.841).Conclusion Hp infection rate in ACI patients is higher than that in normal people.The increased levels of serum Hcy and FIB,and APTT shortening in ACI patients are related to Hp infection.