乳腺癌患者血清E-cadherin、sE-cadherin水平与临床分期及化疗疗效的相关性

Correlation between serum E-cadherin and sE-cadherin levels and clinical stage and chemotherapy efficacy in patients with breast cancer

目的:探究乳腺癌患者血清E-cadherin、sE-cadherin水平与临床分期及化疗疗效之间的相关性。方法:本研究收集我院2017年1月~2018年11月接受治疗的患者资料100例,按TNM分期标准进行分期,分别检测其血清E-cadherin、sE-cadherin水平,比较TNM分期与血清两指标之间相关性;再检测蒽环联合紫杉醇化疗后患者血清两指标水平,对比不同化疗效果患者血清两指标,并分析其相关性。结果:患者血清E-cadherin水平随着临床分期升高而明显降低,sE-cadherin和HMGB1水平则随着临床分期升高而明显升高;血清E-cadherin水平与临床分期呈负相关,sE-cadherin水平与临床分期呈正相关,相关系数分别为-0.357和0.382;化疗后,CR+PR组E-cadherin水平明显高于化疗前,sE-cadherin和HMGB1水平明显低于于化疗前,而SD+PD组合与化疗前无明显差距但明显异于CR+PR组;血清E-cadherin水平与化疗疗效呈负相关,sE-cadherin水平与临床分期呈正相关,相关系数分别为-0.310和0.326。结论:不同TNM分期患者血清E-cadherin、sE-cadherin水平不同,E-cadherin水平与临床分期呈负相关,sE-cadherin与临床分期呈正相关;化疗前后检测血清E-cadherin、sE-cadherin水平可帮助表征乳腺癌预后和复发情况,为临床诊断和治疗提供依据。

Objective To investigate the correlation between serum E-cadherin and sE-cadherin levels and clinical stage and chemotherapy response in breast cancer patients.Methods This study collected 100 patients with data from January 2017 to November 2018 in our hospital.The patients were enrolled according to TNM staging criteria.Serum levels of E-cadherin and sE-cadherin were measured.TNM staging and serum were compared.Correlation between the two indexes of serum in patients with anthracycline combined with paclitaxel,and the two indexes of serum in patients with different chemotherapy effects were compared and their correlations were analyzed.Results Serum E-cadherin levels were significantly decreased with clinical stage,and sE-cadherin and HMGB1 levels were significantly increased with clinical stage.Serum E-cadherin The level was negatively correlated with clinical stage.The level of sE-cadherin was positively correlated with clinical stage,and the correlation coefficients were-0.357 and 0.382 respectively.After chemotherapy,the level of E-cadherin in CR+PR group was significantly higher than that before chemotherapy,sE-cadherin and HMGB1 levels were significantly lower than before chemotherapy,but there was no significant difference between SD+PD combination and chemotherapy but significantly different from CR+PR group.Serum E-cadherin levels were negatively correlated with chemotherapy efficacy,and sE-cadherin levels were positively correlated with clinical stage,with correlation coefficients of-0.310 and 0.326,respectively.Conclusion The levels of serum E-cadherin and sE-cadherin are different in different TNM patients.E-cadherin level is negatively correlated with clinical stage.sE-cadherin is positively correlated with clinical stage.Serum E-cadherin and sE-cadherin levels before and after chemotherapy can help.Characterize the prognosis and recurrence of breast cancer,and provide evidence for clinical diagnosis and treatment.