泮托拉唑钠联合克林霉素、阿莫西林治疗Hp阳性十二指肠溃疡患者对其血清肽类胃肠激素及TGF-β1水平的影响

Effect of pantoprazole sodium combined with clindamycin and amoxicillin in the treatment of Hp positive duodenal ulcer patients on the levels of serum peptide,gastrointestinal hormones and TGF-beta 1

目的:探究泮托拉唑钠联合克林霉素、阿莫西林治疗幽门螺杆菌(Hp)阳性十二指肠溃疡患者对其血清肽类胃肠激素及TGF-β1水平的影响。方法:选取我院自2016年5月~2017年5月收治的Hp阳性十二指肠溃疡患者100例,按照随机数字表法将其平均分为观察组和对照组,每组50例。对照组患者给予奥美拉唑联合克林霉素、阿莫西林治疗治疗,观察组患者给予泮托拉唑钠联合克林霉素、阿莫西林治疗,两组患者治疗后随访2个月。记录并统计两组患者一般情况(性别、年龄、BMI、病程)、胃肠激素胃泌素(Gas)、肾上腺髓质素(AM)、胃动素(MTL)、生长抑素(SS)和降钙素基因相关肽(CGRP)、血清转化生长因子β1(TGF-β1)浓度水平。结果:两组患者一般情况比较无明显差异。两组患者Gas、AM、MTL比较差异明显,随着治疗的进行,两组患者Gas、AM、MTL均有所降低,但观察组患者降低程度明显大于对照组;两组患者SS、CGRP比较差异明显,随着治疗的进行,两组患者SS、CGRP均有所升高,但观察组患者升高程度明显大于对照组;两组患者TGF-β1比较差异明显,随着治疗的进行,两组患者TGF-β1均有所降低,但观察组患者降低程度明显大于对照组,经秩和检验,两组患者疗效比较差异明显,且对照组总有效率为76.0%,观察组总有效率为96.0%,明显高于对照组。结论:泮托拉唑钠联合克林霉素、阿莫西林能有效改善Hp阳性十二指肠溃疡患者血清肽类胃肠激素及炎症水平,有助于胃肠道功能改善。

Objective To explore the effects of pantoprazole sodium combined with clindamycin and amoxicillin on serum levels of peptide,gastrointestinal hormones and TGF-beta 1 in patients with Hp positive duodenal ulcer.Methods Methods from May 2016 to May 2017,100 cases of Hp positive duodenal ulcer patients in a hospital were selected and divided into the observation group and the control group according to the random number table method,50 cases in each group.The control group was treated with omeprazole combined with clindamycin and amoxicillin.The observation group was treated with pantoprazole sodium combined with clindamycin and amoxicillin.The two groups were followed up for 2 months after treatment.The general situation of records and statistics of two groups of patients(gender,age,BMI,duration),gastrointestinal hormone gastrin(Gas),adrenomedullin(AM)and motilin(MTL),somatostatin(SS)and calcitonin gene related peptide(CGRP),serum transforming growth factor beta 1(TGF-beta 1)the level of concentration.Results The general situation of the two groups had no significant difference,with no statistical significance.There were significant differences in Gas,AM and MTL between the two groups,compared with the treatment,two groups of patients with Gas,AM and MTL were lower,but the patients in the observation group was remarkably higher than that of control group;SS and CGRP were significantly different between the two groups,compared with treatment the two groups of patients,SS and CGRP were increased,but the patients in the observation group increased significantly than the control group;There was significant difference in TGF-β1 between the two groups,compared with the treatment,two patients in group TGF-beta 1 were lower,but the observation group of patients was remarkably higher than that of control group,by rank sum test,compare the efficacy of two groups were significant and the control group,the total effective rate was 76%,the total efficiency of the observation group was 96%,significantly higher than the control Group,with statistical significance.Conclusion Pantoprazole sodium combined with clindamycin and amoxicillin can effectively improve the serum levels of peptide,gastrointestinal hormones and inflammation in patients with Hp positive duodenal ulcer,which is helpful for improving gastrointestinal function.