卡贝缩宫素防治高危妊娠产后出血的效果及对凝血相关因子水平影响

Effect of capectin on preventing and treating postpartum hemorrhage in high-risk pregnancy and its effect on coagulation related factors

目的:分析卡贝缩宫素防治高危妊娠产后出血的效果及对凝血相关因子水平影响。方法:选取我院(2014年12月~2018年1月)收治有高危因素的剖宫产产妇114例,随机分为对照组(地塞米松+卡前列素氨丁三醇)和观察组(地塞米松+卡前列素氨丁三醇+卡贝缩宫素),分析两组产妇治疗后的临床效。结果:给药前,两组产妇血压、心率水平比较,差异无统计学意义。给药0.5h,观察组产妇血压、心率水平与对照组比较,差异无统计学意义。给药前,两组产妇纤溶酶-抗纤溶酶复合物(PAP)、凝血酶-抗凝血酶复合物(TAT)、纤维蛋白原(Fib)、D-二聚体(D-D)水平比较,差异无统计学意义。给药12h、24h,观察组产妇TAT水平高于对照组,PAP、Fib、D-D水平低于对照组,差异有统计学意义。观察组产妇术中出血量、术后2h及24h出血量均少于对照组,Hb下降值低于对照组,不良反应率率低于对照组,差异有统计学意义。结论:卡贝缩宫素防治高危妊娠产后出血可调节凝血相关因子水平,减少出血量,且安全性高。

Objective To analyze the effect of capectin on preventing and treating high-risk postpartum hemorrhage of pregnancy and its influence on coagulation-related factors.Methods From December 2014 to January 2018,114 cases of cesarean section with high risk factors were treated in our hospital.The control group(dexamethasone carprostatin aminobutanol)and the observation group(dexamethasone carprostatin amitriol capectin)were randomly divided into two groups.Results Before administration,there was no significant difference in blood pressure and heart rate between the two groups.The difference was not statistically significant compared with the control group(0.5h).Before administration,the levels of plasminase-antiplasmin complex(PAPP),thrombin/antithrombin complex(TATT),fibrinogen(Fibn),D-dimer(D-D)were not significantly different between the two groups.The level of tat in the observation group was higher than that in the control group,and the level of D-D in the control group was lower than that in the control group.The amount of intraoperative bleeding and the amount of blood loss at 2 and 24 hours after operation were lower than those in the control group,and the adverse reaction rate was lower than that in the control group.Conclusion The prevention and treatment of postpartum hemorrhage in high risk pregnancy by capectin can regulate the level of coagulation related factors,reduce the amount of bleeding,and have high safety.