CBX7和TAZ在喉鳞状细胞癌中的表达及其与临床病理特征的相关性

Expression Levels of CBX7 and TAZ in Laryngeal Squamous Cell Carcinoma and Its Correlation with Clinicopathological Features

目的:探究色素框同源蛋白7(CBX7)和具有PDZ结合域的转录共激活因子(TAZ)在喉鳞状细胞癌中的表达及其与临床病理特征的相关性。方法:选择2009年3月~2018年2月我院收治的67例喉鳞状细胞癌患者的蜡块样本资料进行回顾性分析,采用免疫组化法检测CBX7和TAZ蛋白在癌组织和正常组织中的表达水平,比较CBX7和TAZ的表达水平与各病理临床特征的关系。结果:CBX7蛋白在喉鳞状细胞癌组织和癌旁正常组织中的高表达率分别为85.07%(57/67)和65.67%(44/67),TAZ蛋白在喉鳞状细胞癌组织和癌旁正常组织中的高表达率分别为76.12%(51/67)和13.43%(9/67),差异均具有统计学意义;TNM分期、组织分化程度及淋巴结转移情况不同的患者癌组织中CBX7蛋白表达水平差异具有统计学意义;发生部位、TNM分期、组织分化程度及淋巴结转移情况不同的患者癌组织中TAZ蛋白表达水平差异具有统计学意义;CBX7和TAZ在喉鳞状细胞癌组织中的表达水平呈正相关。结论:CBX7和TAZ在喉鳞状细胞癌中呈高表达趋势;且CBX7的表达水平与TNM分期、组织分化程度、淋巴结转移情况有关;TAZ的表达水平与发生部位、TNM分期、组织分化程度、淋巴结转移情况有关;CBX7和TAZ在喉鳞状细胞癌组织中的表达水平呈正相关。

Objective To investigate the expression levels of chromobox protein homolog 7(CBX7)and transcriptional coactivator with PDZ-binding motif(TAZ)in laryngeal squamous cell carcinoma and its correlation with clinicopathological features.Methods The wax samples of 67 patients with laryngeal squamous cell carcinoma admitted to our hospital from March 2009 to February 2018 were retrospectively analyzed.In this study,then the correlation of CBX7 and TAZ expression levels with the pathological features was analyzed.Results The high expression rates of CBX7 and TAZ proteins in laryngeal squa-mous cell carcinoma tissues and adjacent normal tissues were 85.07%(57/67)&65.67%(44/67),76.12%(51/67)&13.43%(9/67),respectively,with statistic difference.The differences were found in the expression level of CBX7 protein among cancer tissues with different stages of TNM,histological differentiation and lymph node metastasis.The expression level of TAZ protein in cancer tissues had difference among cancer tissues with different sites of occurrence,TNM stage,histological differentiation and lymph node metastasis.The expression levels of CBX7 and TAZ in laryngeal squamous cell carcinoma were positively correlated.Conclusion CBX7 and TAZ protein are highly expressed in the laryngeal squamous cell carcinoma tissues,and the expression level of CBX7 is correlated with TNM stage,histological differentiation,lymph node metastasis,moreover,the TAZ expression level is related with the lesions location,TNM stage,histological differentiation,lymph node metastasis.Furthermore,the expression levels of CBX7 and TAZ in laryngeal squamous cell carcinoma are positively correlated.