人类TMEM121基因的生物信息学分析

Bioinformatic Analysis of the TMEM121 Gene in Homo Sapiens

目的:以人类心肌特异性表达基因TMEM121为研究部对象,对其编码蛋白的结构和功能进行预测。方法:利用生物信息学方法对TMEM121蛋白的同源度、二级结构、互作蛋白及功能等进行预测分析。结果:TMEM121蛋白在进化上高度保守,与猩猩、绿猴、家猫、大鼠及小鼠等的同源度高达96%以上,主要二级结构是α螺旋,无信号肽,定位于内质网的可能性比较大,具有转运及信号转导等功能。结论:人类TMEM121基因可能作为转运和信号转导因子与其他蛋白共同作用参与成体心脏功能的调控。

Objective To analyze the structure and function of TMEM121 protein with bioinformatics.Methods The bioinformatic methods and tools were used to analyze the homology,secondary structure and functional category of TMEM121 protein.Results The bioinformatic analysis revealed that the proline content of TMEM121 protein was highly conserved in evolution,the main secondary structure element was alpha helix,and etc.The TMEM121 protein were mainly localized in endoplasmic reticulum and played a role in transporter regulation and signal transducer.Conclusion Human TMEM121 gene may act as signal transducer factor participating in adult cardiac function.