2016-2019年漯河市临颍县疑似预防接种异常反应监测分析

Monitoring and analysis of adverse events following immunization in Linying, Luohe, from 2016 to 2019

目的了解2016-2019年临颍县疑似预防接种异常反应的发生特征。方法通过中国免疫规划信息管理系统导出2016-2019年临颍县报告的AEFI个案数据,疫苗接种剂次数据来源于河南省免疫规划信息管理系统,采用描述性流行病学方法对AEFI监测数据进行分析。结果2016-2019年临颍县共报告AEFI病例645例,报告发生率为91.42/10万剂;其中一般反应606例,占93.95%;异常反应32例,占4.96%;偶合症7例,占1.09%。全县AEFI报告覆盖率达100%,AEFI发现后48 h内报告率为100%;0~2岁报告最多475例,占73.64%;<12月龄婴幼儿AEFI例数最多的为8~9月龄112例,占35.78%。AEFI发生间隔多在接种1 d内,625例,占96.90%。临床诊断以发热/红肿/硬结最多,606例,占93.95%;其次为过敏性皮疹21例,占3.26%。AEFI报告发生率较高的疫苗为麻风疫苗、乙脑减毒活疫苗、百白破疫苗(无细胞),报告发生率(/10万剂)分别为381.71、228.85、144.11。结论2016-2019年临颍县AEFI监测系统灵敏性较高,疫苗安全性良好。

Objective To investigate the characteristics of adverse events following immunization(AEFI)in Linying county from2016 to 2019.Methods AEFI case data reported in Linying county from 2016 to 2019 were extracted from China Immunization Program Information Management System.The vaccine dose data were obtained from Henan Provincial Immunization Planning Information Management System.The AEFI monitoring data were analyzed with descriptive epidemiological method.Results A total of 645 AEFI cases were reported in Linying county from 2016 to 2019,the reported incidence rate was 91.42 cases/100000 doses;among them,606 cases were general reaction,accounting for 93.95%;32 cases were abnormal reaction,accounting for4.96%;7 cases were coincidence syndrome,accounting for 1.09%.The report-coverage rate of AEFI was 100%in the whole county,and reporting rate was 100%within 48 hours after AEFI was found;475 cases(73.64%)were reported at 0-2 years old,accounting for 73.64%;112 cases(35.78%)were between 8-9 months old,accounting for the highest number of the cases less than 12 months old.AEFI occurred in 625 cases(96.90%)within one day after inoculation.The most common clinical diagnosis was fever/redness/induration(606 cases,93.95%),followed by allergic rash(21 cases,3.26%).Leprosy vaccine,live attenuated Japanese encephalitis vaccine and diphtheria pertussis vaccine(acellular)had higher incidence of AEFI reports,with the reported incidence rates of 381.71,228.85 and 144.11/100000 doses,respectively.Conclusion AEFI monitoring system in Linying county from 2016 to 2019 has high sensitivity,and vaccine safety is good.