河南省某县24349例孕产妇乙型病毒性肝炎血清学检测分析

Serological test results of 24 349 pregnant women with hepatitis B in one county of Henan province

目的研究河南叶县地区孕产妇人群中乙肝的感染状况,以制定有效的防控和治疗方案,为进一步改进和完善乙肝母婴传播阻断策略提供参考依据。方法研究2015-2019年于叶县人民医院就诊的所有孕产妇24349例,运用酶联免疫(ELISA)方法对就诊的孕产妇进行乙型肝炎病毒相关指标的定性检测,通过分析其血清中乙肝病毒抗原、抗体检测结果,研究孕产妇人群中乙型肝炎病毒感染及乙肝免疫保护状况的年龄、时间分布。结果24349例孕产妇中HBsAg阳性率2.75%,HBsAb阳性率38.24%,HBeAg阳性率0.74%,HBeAb阳性率4.94%,HBcAb阳性率11.24%;年龄分组显示年龄越大,HBV感染率越高(P<0.05)。结论应持续提升HBV传播的母婴阻断率,尤其应关注大龄孕产妇。

Objective To study the status of hepatitis B virus(HBV)infection in pregnant women in Yexian county,Henan province,in order to formulate effective prevention,control and treatment plans,and to provide a reference for further improving and perfecting the strategy of blocking mother-to-child transmission of hepatitis B.Methods A total of 24349 pregnant women who attended Yexian People’s Hospital from 2015 to 2019 were enrolled in this study.Enzyme-linked immunosorbent assay(ELISA)method was used to qualitatively detect HBV-related biomarkers in the pregnant women.Based on the serum test results for the virus antigen and antibody,the age and year distribution of HBV infection and immune protection in pregnant women were analyzed.Results In the 24349 pregnant women,the positive rates of HBsAg,HbsAb,HbeAg,HbeAb and HbcAb were 2.75%,38.24%,0.74%,4.94%and 11.24%,respectively.The analysis by age group showed that the older the age was,the higher the HBV infection rate was(P<0.05).Conclusion The rate of blocking mother-to-child transmission of HBV should be continuously increased,especially for older pregnant women.