2019年河南省慢性病监测点医院就诊者丙型肝炎感染状况调查

Survey on hepatitis C infection among patients in chronic disease surveillance hospitals in Henan province,2019

目的了解慢性病监测点医院就诊人群丙肝感染状况,探讨采用医院就诊者丙肝感染状况描述当地丙肝流行状况的可行性。方法选择河南省慢性病监测点所在的4个县区作为调查点,采用连续抽样的方法,对调查期间符合入选标准的就诊者进行调查,并进行抗-HCV和HCV RNA检测。结果共调查医院就诊者5980例,抗-HCV阳性率为0.75%(95%CI:0.74%~0.76%),HCV RNA阳性率为0.35%(95%CI:0.34%~0.36%),与2012年河南省抽样调查标化后的全人群抗-HCV和HCV RNA阳性率(分别为0.64%和0.35%)相比,差异无统计学意义(P均>0.05)。25岁以下未发现抗-HCV阳性者,25岁及以上各年龄组抗-HCV和HCV RNA阳性率均随年龄增长而升高,差异有统计学意义(P均<0.05)。结论河南省调查地区医院就诊者抗-HCV和HCV RNA阳性率与全人群抽样调查结果接近,可考虑采用医院就诊者丙肝感染状况描述当地丙肝流行状况。

Objective To investigate the status of hepatitis C infection in hospitals of chronic disease monitoring points,and to explore the feasibility of using the status of hepatitis C infection among patients in hospitals to describe the local hepatitis C epidemic situation.Methods Four counties and districts of chronic disease surveillance points in Henan Province were selected,the patients who met the inclusion criteria during the survey were investigated by continuous sampling,and the anti-HCV and HCV RNA were detected.Results A total of 5980 cases were investigated,the anti-HCV rate of the patients was 0.75%(95%CI:0.74%-0.76%),HCV RNA positive rate was 0.35%(95%CI:0.34%-0.36%).There was no significant difference(P>0.05)between the standardized anti-HCV(0.64%)and HCV RNA positive rates(0.35%)in Henan Province in 2012.No anti-HCV positive cases were found less than 25 years old,the positive rates of anti-HCV and HCV RNA in 25 years old and above groups increased with age,and the difference was statistically significant(P<0.05).Conclusion The positive rates of anti-HCV and HCV RNA among the hospital patients in Henan were close to the results of the whole population,so we should use the HCV infection status of the patients to describe the local HCV epidemic situation.