安阳市2345例疑似布鲁氏菌病血清抗体检测结果分析

Analysis of serum antibody test results of 2345 outpatients with brucellosis in Anyang City

目的通过对2017-2018年安阳市疾病预防控制中心门诊2345例疑似布鲁氏菌病(简称布病)血清抗体检测结果分析,了解安阳市布病流行特征,为防治布病提供科学依据。方法依照《布鲁氏菌病诊断标准》(WS269-2007),2345份血清做虎红平板凝集试验(RBPT)和试管凝集试验(SAT)血清抗体检测,结果用流行病学方法进行分析。结果2345例血清抗体检测结果显示,阳性人数416例,阳性率17.74%。男性阳性率21.73%(304/1399),女性阳性率11.84%(112/946),男女性别阳性率差异具有统计学意义(χ2=37.83,P<0.01);4-7月为发病高峰;发病年龄段在41~50岁之间高发,阳性率27.88%,各年龄组阳性率差异具有统计学意义(χ2=38.03,P<0.01);职业分布以养殖户及屠宰加工业为主;高发地区为安阳县、林州市、内黄县、滑县,其中以安阳县阳性率21.53%最高。结论安阳市布病易感人群以农民养殖户及屠宰加工业的密切接触者为主,提高职业人群的防病意识为重中之重,加大对布病的防治知识宣传教育力度,做到早发现、早诊断、早治疗,有效控制布病发生及发展。

Objective This study aims to understand the epidemic characteristics of brucellosis in Anyang City and to provide scientific evidence for its prevention and treatment.Thus,serum antibody samples were collected and analyzed from 2345 outpatients from the Centre for Disease Control and Prevention in Anyang,during 2017-2018.Methods According to the Diagnostic Criteria for Brucellosis(WS269-2007),2345 sera were tested for RBPT and SAT serum antibodies.The results were then analyzed by epidemiological methods.Results The results of serum antibody test in 2345 cases showed that 416 of which were positive,with positive rate of 17.74%.The positive rate was 21.73%(304/1399)in the male and 11.84%(112/946)in the female.There was a significant difference in the results between two genders(χ~2=37.83,P<0.01).The incidence of brucellosis peaked in April-July.The incidence rate also reached the highest in the age group of 40-50,with positive rate of 27.88%,showing a significant statistical difference(χ~2=38.03,P<0.01).Occupational distribution was dominated by farmers,breeders and slaughtering and processing industries.High incidence areas were found to be Anyang County,Linzhou City,Neihuang County and Huaxian County,with the highest positive rate of 21.53%(146/678)in Anyang County.Conclusion Close contacts of farmers,breeders and slaughtering industry workers are the main susceptible groups to brucellosis in Anyang City.Increasing the awareness of prevention and treatment of the disease are the main priority.We should intensify the propaganda and education about brucellosis as to achieving early detection and diagnosis of the disease,thereby providing effective treatment and controlling the epidemic.