2013-2018年河南省漯河市无偿献血人群梅毒感染状况分析

Analysis of TP infection status among voluntary blood donors in Luohe area of Henan Province from 2013 to 2018

目的探讨漯河地区无偿献血人群梅毒螺旋体(TP)感染情况,为无偿献血招募和确保输血安全提供依据。方法采用ELISA法对165284例无偿献血者血液标本进行抗-TP筛查,结果呈反应性者应用TPPA法确认,对不同特征献血人群梅毒结果进行分析。结果165284例献血者抗-TP初筛反应性589例(0.36%),273例(0.17%)梅毒确证阳性;女性梅毒阳性率(0.23%)高于男性(0.12%),初次献血阳性率(0.46%)高于多次献血(0.05%),已婚献血者阳性率(0.19%)高于未婚献血者(0.14%),差异均有统计学意义(P<0.05);21~30岁年龄段献血者梅毒阳性率最高,不同年龄段献血者梅毒阳性率差异有统计学意义(P<0.05);273例梅毒确阳性者中,单纯TP阳性267例(97.80%),TP+HIV合并感染5例(1.83%),TP+HIV+HCV合并感染1例(0.37%)。结论漯河地区无偿献血人群存在一定程度梅毒阳性率,多发生于初次献血的已婚女性人群,加强对高危人群献血前征询和健康检查,可减少/阻断梅毒传播。

Objective To explore TP infection status of voluntary blood donors in Luohe area, so as to provide basis for the recruitment of blood donors and ensure blood safety in clinic. Methods A total of 165 284 blood specimens of voluntary blood donors were screened for anti-TP by ELISA, all the specimens of preliminary screening responsivity were confirmed by TPPA, and the distribu-tion characteristics of TP results in different population were analyzed. Results 589 cases(0.36%) were confirmed with TP-positive among 165 284 blood specimens, and 273 cases ascertainment positive;the TP-positive rate(0.23%) of female was higher than that of male(0.12%), the TP-positive rate(0.46%) of primary blood donation group was higher than that of multi-donation group(0.05%), the positive rate(0.46%) of married blood donation group was higher than that of unmarried blood donation(0.05%), there was statistically significant difference between two groups(P <0.05);the TP-positive rate was highest of 20 ~30 age stage blood donor, there was statistically significant difference between different age stage(P<0.05);in 273 cases ascertainment positive, simple TP-positive 267 cases(97.80%), a total of 5 cases of TP+HIV concurrent infection, 1 cases of TP+HIV+HCV concurrent infection.Conclusion There was positive rate of TP in voluntary blood donors, the most prevalent TP infected individuals were married female, health consultation before blood donation and recruitment blood donors from lower risk groups should be strengthened to decrease/intercept TP spreading.