呋喃磺草酮关键中间体的合成工艺研究

Synthesis of Key Intermediates of Terfuryltrione

以3-氯-2甲基苯胺(■)为原料,经过重氮化反应、取代反应得到2-氯-6-甲硫基甲苯(■),优化条件下,收率达92.07%。■经过傅-克酰基化反应得到2-氯-4-甲硫基-3-甲基苯乙酮(■),优化条件下收率为90.58%。■和■均经~1H NMR确证结构。该制备方法三废少、收率高,具有工业化应用前景。

2-Chloro-6-methylthio toluene(■)was synthesized from 3-chloro-2-methylaniline(■)as raw material through diazotization and substitution reaction,with the yield 92.07%.Then 2-chloro-3-methyl-4-methylthioacetophenone(■)was synthesized from compound■through Friedel-Crafts acylation,with the yield 90.58%.Both compound■and compound■were confirmed by^1H NMR.The routes showed the advantages of low waste and high yield.