自然流产与孕妇TORCH感染关系的荟萃分析

Meta-analysis of the Relationship Between Spontaneous Abortion and TORCH Infection in Pregnant Women

目的通过Meta分析评价孕妇感染TORCH与自然流产的相关性,为孕妇优生优育和临床治疗提供支持。方法利用关键词检索中国知网(China national knowledge infrastructure,CNKI)、万方、PubMed等数据库获得文献4180篇,根据纳入标准进行筛选,共纳入研究25篇,观察组孕妇5852例,对照组孕妇19944例。结果Meta分析发现,观察组(有自然流产史的孕妇)TORCH-IgM抗体阳性率分别为弓形虫(toxoplasma,TOX)-IgM 14.67%、风疹病毒(rubella virus,RV)-IgM 8.59%、巨细胞病毒(cytomegalovirus,CMV)-IgM 15.36%、单纯疱疹病毒(herpes simplex virus,HSV)-IgM 15.70%;对照组(无自然流产史的孕妇)TORCH-IgM抗体阳性率分别为TOX-IgM 0.56%、RV-IgM 0.58%、CMV-IgM 1.03%、HSV-IgM 0.50%。观察组TORCH-IgM抗体阳性率显著高于对照组,差异具有统计学意义(P<0.00001)。结论有自然流产史的孕妇TORCH感染率较正常孕妇高,HSV的感染率更高,此结果可以为TORCH感染的预防和治疗提供流行病学依据,引起育龄妇女和孕妇关注和预防TORCH感染。

Objective To evaluate the correlation between TORCH infection and spontaneous abortion in pregnant women,so as to provide support for pregnant women′s eugenics and clinical treatment.Methods A total of 4180 literatures were obtained by searching China national knowledge infrastructure(CNKI),Wanfang,PubMed and other databases.According to inclusion criteria,25 literatures were included in the study,5852 pregnant women in the observation group and 19944 pregnant women in the control group.Results Meta-analysis showed that the antibody positive rate of TORCH-IgM in the observation group(pregnant women with history of spontaneous abortion)was toxoplasma(TOX)-IgM 14.67%,rubella virus(RV)-IgM 8.59%,cytomegalovirus(CMV)-IgM 15.36%and herpes simplex virus(HSV)-IgM 15.70%respectively,and that in the control group(pregnant women without history of spontaneous abortion)was TOX-IgM 0.56%,RV-IgM 0.58%,CMV-IgM 1.03%and HSV-IgM 0.50%respectively.The antibody positive rate of TORCH-IgM in the observation group was significantly higher than that in the control group(P<0.00001).Conclusion The infection rate of TORCH in pregnant women with a history of spontaneous abortion is higher than that in normal pregnant women,and the infection rate of HSV is higher.This result can provide epidemiological basis for the prevention and treatment of TORCH infection,and attract the attention of women of childbearing age and pregnant women and prevent TORCH infection.