膦甲酸钠联合神经妥乐平治疗带状疱疹的疗效分析

Effects Analysis of Foscarnet Sodium Combined with Neurotropin in the Treatment of Herpes Zoster

目的观察膦甲酸钠联合神经妥乐平治疗带状疱疹的临床疗效。方法将入选的180例带状疱疹患者随机分为3组,每组60例。A组采用膦甲酸钠联合神经妥乐平治疗,B组采用膦甲酸钠治疗,C组采用阿昔洛韦治疗,疗程均为7 d。记录3组患者止疱、结痂和疼痛减轻30%所需时间及药物不良反应,第八天比较3组神经疼痛评分和疗效,1个月时比较3组患者带状疱疹后神经痛发生率。结果A组和B组患者止疱、结痂及疼痛减轻30%所需时间均明显短于C组(P<0.01),且A组疼痛减轻30%所需时间明显短于B组(P<0.01)。3组治疗后神经疼痛评分均较治疗前明显降低(P<0.01),其中A组评分最低,B组次之,组间比较差异均有统计学意义(P<0.01或P<0.05)。A、B、C组治愈率分别为75.93%、54.72%和34.62%,有效率分别为90.74%、73.58%和51.92%,差异有统计学意义(P<0.05)。A、B、C组后遗神经痛发生率分别为1.85%、11.32%和30.77%,差异有统计学意义(P<0.05)。3组药物不良反应发生率差异无统计学意义(P<0.05)。结论膦甲酸钠联合神经妥乐平治疗带状疱疹临床疗效好,可有效缩短止疱、结痂及疼痛缓解时间,减轻急性期疼痛,减少带状疱疹后神经痛发生。

Objective To observe the clinic effects of foscarnet sodium combined with neurotropin in the treatment of herpes zoster.Methods A total of 180 patients with herpes zoster were randomly divided into three groups,60 in each group.Group A was treated with foscarnet sodium combined with neurotropin,group B was treated with foscarnet sodium,and group C was treated with acyclovir,with a course of 7 days.The time required for antibullous,scab formation,pain reduction of 30%and adverse drug reactions of patients in the three groups were recorded.On the 8 th day,the neuropathic pain scores and clinical curative effect in the three groups were compared,and the incidence of postherpetic neuralgia was compared at 1 month.Results The time required for antibullous,scab formation and pain reduction of 30%in group A and group B were significantly shorter than those in group C(all P<0.01),and the time required for pain reduction of 30%in group A was also significantly shorter than that in group B(P<0.01).The neuropathic pain scores in the three groups after treatment were significantly lower than those before treatment(all P<0.01),and the neuropathic pain scores were the lowest in group A and the second in group B,the differences were statistically significant among the three groups(P<0.01 or P<0.05).The cure rates of group A,B and C were 75.93%,54.72%and 34.62%,respectively,and the effective rates were 90.74%,73.58%and 51.92%,respectively,there were significant differences among the three groups of the cure rates and effective rates(P<0.01 or P<0.05).The incidence of postherpetic neuralgia in groups A,B and C was 1.85%,11.32%and 30.77%,respectively,with statistically significant differences(P<0.01 or P<0.05).There was no significant difference in the incidence of adverse drug reactions among the three groups(P>0.05).Conclusion Foscarnet sodium combined with neurotropin is effective in the treatment of herpes zoster,which can shorten the time of antibullous,scab formation and pain relief,reduce acute pain and the occurrence of postherpetic neuralgia.