摘要
目的探讨胆红素血脂综合指数和尿酸(uric acid,UA)水平与急性冠状动脉综合征(acute coronary syndrome,ACS)患者冠状动脉病变程度的关系。方法将218例ACS患者分为3组:急性ST段抬高型心肌梗死患者86例(STEMI组,n=86),急性非ST段抬高型心肌梗死患者53例(NSTEMI组,n=53),不稳定型心绞痛患者79例(UAP组,n=79),同时选择50例冠状动脉狭窄<50%的患者为冠状动脉粥样硬化组(对照组)。分别测定全部患者的血清总胆红素(total bilirubin,TBIL)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、以及UA水平,计算出胆红素血脂综合指数[TC/(HDL-C+TBIL)、LDL-C/(HDL-C+TBIL)],并与冠状动脉积分做相关性分析。结果①ACS患者中STEMI组、NSTEMI组、UAP组TBIL水平较对照组低,差异有统计学意义(P<0.01或0.05);TC、LDL-C、UA、TC/(HDL-C+TBIL)、LDL-C/(HDL-C+TBIL)水平较对照组高,差异有统计学意义(P均<0.01)。②在不同的冠状动脉病变积分中,UA、TC/(HDL-C+TBIL)、LDL-C/(HDL-C+TBIL)的差异均有统计学意义(P<0.05),与冠状动脉病变积分呈正相关。③相关性分析显示:UA与冠状动脉病变积分呈正相关(r=0.288,P<0.05),TC/(HDL-C+TBIL)、LDL-C/(HDL-C+TBIL)亦与冠状动脉病变积分呈正相关(r=0.121,P<0.05;r=0.145,P<0.05)。结论ACS患者胆红素血脂综合指数、UA水平较对照组患者显著升高;ACS患者胆红素血脂综合指数、UA水平与其冠状动脉病变程度密切相关。
Objective To explore the relationship between the levels of bilirubin blood lipid comprehensive index,uric acid(UA)and the severity of coronary artery lesions in patients with acute coronary syndrome(ACS).Methods A total of 218 patients with acute coronary syndrome were divided into three groups:patients with acute ST segment elevation myocardial infarction(STEM group,n=86),patients with acute non-ST-segment elevation myocardial infarction(NSTEM group,n=53),patients with unstable angina(UAP group,n=79),at the same time,50 patients with coronary artery stenosis less than 50%were selected as coronary atherosclerosis group(control group,n=50).The levels of total bilirubin(TBIL),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),UA were determined.TC/(HDL-C+TBIL),LDL-C/(HDL-C+TBIL)were calculated,the correlation between coronary artery score and result was analyzed.Results①Compared with control group,the levels of TBIL of UAP group,NSTEMI group and STEMI group were decreased(all P<0.01 or 0.05);but the levels of TC,LDL-C,UA,TC/(HDL-C+TBIL),LDL-C/(HDL-C+TBIL)were increased(all P<0.01).②In different coronary artery integrals,TC/(HDL-C+TBIL),LDL-C/(HDL-C+TBIL)and UA were positively correlated with coronary lesion integrals(P<0.05).③Correlation analysis presented that TC/(HDL-C+TBIL),LDL-C/(HDL-C+TBIL)and UA were positively related to coronary artery integrals(r=0.121,0.145,0.288 respectively,all P<0.05).Conclusion The levels of UA,TC/(HDL-C+TBIL),LDL-C/(HDL-C+TBIL)with ACS were significantly higher than those in control group.The levels of UA,TC/(HDL-C+TBIL),LDL-C/(HDL-C+TBIL)in patients with ACS were closely related to the degree of coronary artery lesion.
作者
夏啸
蒋桔泉
XIA Xiao;JIANG Juquan(First Clinical college of Hubei University of Traditional Chinese Medicine,Wuhan Hubei 430061,China)
出处
《华南国防医学杂志》
CAS
2020年第2期100-104,共5页
Military Medical Journal of South China
关键词
急性冠状动脉综合征
胆红素血脂综合指数
尿酸
Acute coronary syndrome
Bilirubin blood lipid comprehensive index
Uric acid