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急性冠状动脉综合征患者胆红素血脂综合指数和尿酸水平与冠状动脉病变程度的关系 被引量:6

The Relationship Between the Levels of Bilirubin Blood Lipid Comprehensive Index,Uric Acid and Severity of Coronary Artery Lesion in Patients with Acute Coronary Syndrome
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摘要 目的探讨胆红素血脂综合指数和尿酸(uric acid,UA)水平与急性冠状动脉综合征(acute coronary syndrome,ACS)患者冠状动脉病变程度的关系。方法将218例ACS患者分为3组:急性ST段抬高型心肌梗死患者86例(STEMI组,n=86),急性非ST段抬高型心肌梗死患者53例(NSTEMI组,n=53),不稳定型心绞痛患者79例(UAP组,n=79),同时选择50例冠状动脉狭窄<50%的患者为冠状动脉粥样硬化组(对照组)。分别测定全部患者的血清总胆红素(total bilirubin,TBIL)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、以及UA水平,计算出胆红素血脂综合指数[TC/(HDL-C+TBIL)、LDL-C/(HDL-C+TBIL)],并与冠状动脉积分做相关性分析。结果①ACS患者中STEMI组、NSTEMI组、UAP组TBIL水平较对照组低,差异有统计学意义(P<0.01或0.05);TC、LDL-C、UA、TC/(HDL-C+TBIL)、LDL-C/(HDL-C+TBIL)水平较对照组高,差异有统计学意义(P均<0.01)。②在不同的冠状动脉病变积分中,UA、TC/(HDL-C+TBIL)、LDL-C/(HDL-C+TBIL)的差异均有统计学意义(P<0.05),与冠状动脉病变积分呈正相关。③相关性分析显示:UA与冠状动脉病变积分呈正相关(r=0.288,P<0.05),TC/(HDL-C+TBIL)、LDL-C/(HDL-C+TBIL)亦与冠状动脉病变积分呈正相关(r=0.121,P<0.05;r=0.145,P<0.05)。结论ACS患者胆红素血脂综合指数、UA水平较对照组患者显著升高;ACS患者胆红素血脂综合指数、UA水平与其冠状动脉病变程度密切相关。 Objective To explore the relationship between the levels of bilirubin blood lipid comprehensive index,uric acid(UA)and the severity of coronary artery lesions in patients with acute coronary syndrome(ACS).Methods A total of 218 patients with acute coronary syndrome were divided into three groups:patients with acute ST segment elevation myocardial infarction(STEM group,n=86),patients with acute non-ST-segment elevation myocardial infarction(NSTEM group,n=53),patients with unstable angina(UAP group,n=79),at the same time,50 patients with coronary artery stenosis less than 50%were selected as coronary atherosclerosis group(control group,n=50).The levels of total bilirubin(TBIL),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),UA were determined.TC/(HDL-C+TBIL),LDL-C/(HDL-C+TBIL)were calculated,the correlation between coronary artery score and result was analyzed.Results①Compared with control group,the levels of TBIL of UAP group,NSTEMI group and STEMI group were decreased(all P<0.01 or 0.05);but the levels of TC,LDL-C,UA,TC/(HDL-C+TBIL),LDL-C/(HDL-C+TBIL)were increased(all P<0.01).②In different coronary artery integrals,TC/(HDL-C+TBIL),LDL-C/(HDL-C+TBIL)and UA were positively correlated with coronary lesion integrals(P<0.05).③Correlation analysis presented that TC/(HDL-C+TBIL),LDL-C/(HDL-C+TBIL)and UA were positively related to coronary artery integrals(r=0.121,0.145,0.288 respectively,all P<0.05).Conclusion The levels of UA,TC/(HDL-C+TBIL),LDL-C/(HDL-C+TBIL)with ACS were significantly higher than those in control group.The levels of UA,TC/(HDL-C+TBIL),LDL-C/(HDL-C+TBIL)in patients with ACS were closely related to the degree of coronary artery lesion.
作者 夏啸 蒋桔泉 XIA Xiao;JIANG Juquan(First Clinical college of Hubei University of Traditional Chinese Medicine,Wuhan Hubei 430061,China)
出处 《华南国防医学杂志》 CAS 2020年第2期100-104,共5页 Military Medical Journal of South China
关键词 急性冠状动脉综合征 胆红素血脂综合指数 尿酸 Acute coronary syndrome Bilirubin blood lipid comprehensive index Uric acid
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