盐酸川穹嗪联合丁苯酞对脑梗死临床疗效观察及安全性分析

Therapeutic Effect and Safety of Chuanqiongzi Hydrochloride Combined with Butylphthalide on Cerebral Infarction

目的探讨盐酸川穹嗪联合丁苯酞治疗对脑梗死的疗效与安全性。方法选取宿州市立医院神经内科2018-10/2019-03收治的110例脑梗死患者,随机分为常规组和川丁联合组。常规组患者予以临床常规治疗,川丁联合组在常规治疗基础上静滴盐酸川穹嗪注射液加口服丁苯酞胶囊治疗;检测患者治疗初期的年龄、性别、并发症、血常规、血生化等一般临床指标;分析患者的美国国立卫生院神经功能缺损评分(national institute of health stroke scale,NIHSS)和日常生活活动量表(activity of daily living scale,ADL)数值;统计不良事件,评价治疗的疗效和安全性。结果治疗初期两组患者一般临床指标无统计学差异(P>0.05)。治疗后与治疗前相比各组NIHSS评分均降低(P<0.01)、ADL评分均增高(P<0.01)。治疗前两组间NIHSS评分和ADL评分均无统计学差异(P>0.05)。治疗后川丁联合组较常规治疗组NIHSS评分显著降低(P<0.05)、ADL评分显著升高(P<0.05)。川丁联合组总有效率92.73%高于常规治疗组的78.18%(P<0.05)。两组患者治疗前后未发生严重不良反应,血常规、肝肾功能等重要生化指标无统计学差异(P>0.05)。结论盐酸川穹嗪联合丁苯酞治疗对脑梗死患者疗效优于常规治疗,且安全性好。

Objective To investigate the efficacy and safety of tetraforazine hydrochloride combined with butylphthalide in the treatment of cerebral infarction.Methods A total of 110 patients with cerebral infarction admitted to neurology department of Suzhou Municipal Hospital from October 2018 to March 2019 were randomly divided into conventional group and Chuanding combined group.The patients in the conventional group were treated with clinical routine treatment,while the patients in the Chuanding combined group were treated by intravenous drip of ligustrazine hydrochloride injection and oral administration of butylphthalide capsule on the basis of routine treatment.The general clinical indicators of patients in the early stage of treatment,such as age,gender,complications,blood routine and blood biochemistry were detected.The national institute of health stroke scale(NIHSS)and activity of daily living scale(ADL)were analyzed.Adverse events were counted,and the efficacy and safety of treatment were evaluated.Results There was no significant difference between the two groups in general clinical indicators at initial stage of treatment(P>0.05).After treatment,NIHSS score were lower(P<0.01)and ADL score were higher(P<0.01)than before treatment.Before treatment,there was no significant difference in NIHSS score and ADL score between the two groups(P>0.05).After treatment,the symptoms of Chuanding group were significantly improved,NIHSS score was significantly reduced(P<0.05),ADL score was significantly increased(P<0.05).The total effective rate of Chuanding group was 92.73%higher than the 78.18%of conventional treatment group(P<0.05).There was no serious adverse reaction between the two groups before and after treatment,and there was no significant difference in blood routine test,liver and kidney function and other important biochemical indicators(P>0.05).Conclusion The therapeutic effect of tetraforazine hydrochloride combined with butylphthalide is better than that of conventional therapy in patients with cerebral infarction,and the safety is good.