补阳还五汤加减治疗冠心病稳定型心绞痛临床研究

目的:分析补阳还五汤加减治疗气虚血瘀型冠心病稳定型心绞痛的临床疗效。选取2020年3月—2021年5月我科收治86例气虚血瘀型冠心病稳定型心绞痛病人,用区组随机化法分为观察组和对照组,每组各43例。将对照组使用常规的西医治疗,观察组在此基础上,联合补阳还五汤加减治疗,疗程为4周。观察这两组患者治疗前后的临床疗效、中医证候积分、血脂变化及不良反应发生情况。结果:观察组总有效率是93.02%,对照组总有效率是83.72%,观察组的总有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗之后,其中医证候积分低于对照组,差异有统计学意义(P<0.05);观察组治疗之后,其TC、TG、LDL-C水平均低于对照组,差异有统计学意义(P<0.05),HDL-C水平高于对照组,差异具有统计学意义(P<0.05);两组不良反应发生率无显著差异(P>0.05)。结论:在常规西医治疗基础上联合补阳还五汤加减,治疗气虚血瘀型的冠心病稳定型心绞痛,可以提高其临床疗效,减轻临床症状,改善脂质代谢,且安全。

To analyze the clinical effect of buyang Huanwu Decoction in treating stable angina pectoris of coronary heart disease with qi deficiency and blood stasis.Methods a total of 86 patients with stable angina pectoris with coronary heart disease of qi-deficiency and blood-stasis type treated in our department from March 2020 to May 2021 were divided into observation group and control group by block randomization method,with 43 cases in each group.The control group was treated with conventional Western medicine,and the observation group was treated with buyang Huanwu Decoction for 4 weeks.The clinical efficacy of TCM syndromes and blood lipid changes and the occurrence of adverse reactions in 2 groups were observed before and after treatment.Results:The total effective rate of observation group was 93.02%,and that of control group was 83.72%.The total effective rate of observation group was higher than that of control group,and the difference was statistically significant(P<0.05).After treatment,the TCM syndrome score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).After treatment,TC TG LDL-C level in observation group was lower than control group,the difference was statistically significant(P<0.05),HDL-C level was higher than control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:On the basis of conventional western medicine treatment,combined with buyanghuwu Decoction,the treatment of stable angina pectoris of coronary heart disease with qi deficiency and blood stasis can improve its clinical efficacy,alleviate clinical symptoms,improve lipid metabolism,and is safe.