期刊文献+

小剂量环孢素联合左旋咪唑治疗非重型再生障碍性贫血效果观察

原文传递
导出
摘要 目的:探索小剂量环孢素联合左旋咪唑治疗非重型再生障碍性贫血的疗效。方法:在我院2017年5月-2019年4月收治的非重型再生障碍性贫血患者中选出87例,随机将患者分成两组,对照组患者给予小剂量环孢素治疗,实验组在对照组基础上给予左旋咪唑治疗。结果:实验组患者的治疗有效率为97.67%,高于对照组的治疗有效率81.82%,P<0.05;实验组患者治疗后的血红蛋白、中性粒细胞计数、网织红细胞计数与对照组比较差异不明显,P>0.05;实验组治疗后的血小板计数高于对照组,且治疗期间的高血压、肾功能损害、牙龈增生发生率均低于对照组,P<0.05。结论:小剂量环孢素联合左旋咪唑治疗NSAA患者疗效确切,不良反应少,值得推广。
作者 马云云
出处 《黑龙江中医药》 2020年第3期53-54,共2页 Heilongjiang Journal of Traditional Chinese Medicine
  • 相关文献

参考文献6

二级参考文献45

  • 1MARSH J C, BALL S E, CAVENAQH J, et al. Guidelines for the diagnosis and management of aplastic anaemia[J]. BrJ Haematol- ogy, 2009, 147(1) : 43 -70.
  • 2SCHEINBERG P, YOUNG N S. How I treat acquired aplastic a- nemia[J]. Blood, 2012, 120(6): 1185-1196.
  • 3SONG M K, CHUNG J S, JO0 Y D, et al. Is the early eyelospo- rine A level predictive of the outcome of immunosuppressive thera- py in severe aplastic anemia? [ J ]. Eur J Haematol, 2009, 83 (1):72-78.
  • 4RIST1TANO A M, PERNA F. Aplastic anemia: immunosuppres- sire therapy in 2010[J]. Pediatr Rep, 2011, 3 Suppl2: e7.
  • 5YAMAQUCHI H, CALADO R T, LY H, et al. Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic a- nemia[J]. N Engl J Med, 2005, 352(14) : 1413 -1424.
  • 6ARMANIOS M Y, CHEN J J, COQAN J D, et al. Telomerase mutations in families with idiopathic pulmonary fibrosis [ J ]. N Engl J Med, 2007, 356(13): 1317-1326.
  • 7MARSH J, SCHREZENMEIER H, MARIN P, et al. Prospective randomized muhicenter study comparing cyeIosporln alone versus the combination of antithymocyte globulin and cyclosporin for treat- ment of patients with nonsevere aplastic anemia : a report from the European Blood and Marrow Transplant (EBMT) Severe Aplastlc Anaemia Working Party[J]. Blood, 1999, 93(7) : 2191 -2195.
  • 8FUKUDO M, YANO I, MASUDA S, et al. Pharmacodynamic anal- ysis of tacrolimus and cyclosporine in living - donor liver transplant patients[J]. Clin Pharmacol Ther, 2005, 78(2) : 168 -181.
  • 9SLOAND E, KIM S, MACIEJEWSKI J P, et al. Intracellular IFN - in circulating and marrow T cells detected by flow eytometry and the response to immunosuppressive therapy in patients with aplastic anemia[J]. Blood. 2002. 100(4): 1185-1191.
  • 10宋丽丽,陈东生,吕永宁.环孢素血药浓度的影响因素分析[J].医药导报,2008,27(1):98-100. 被引量:14

共引文献41

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部