B族链球菌阳性母亲母乳喂养致新生儿迟发性感染研究进展

A review of neonatal late-onset infection disease associated with breastfeeding by group B streptococcal positive mother

侵袭性B族链球菌(group B streptococcus,GBS)疾病是新生儿死亡和严重感染的主要原因之一。母乳是新生儿迟发性GBS感染的潜在来源,虽然母乳中含免疫因子,但是GBS阳性母亲的母乳喂养也给新生儿带来了一定的感染风险。GBS阳性母亲行母乳喂养存在争议,目前尚无统一的临床实践指南。本文综述了新生儿GBS感染的流行病学、新生儿迟发性GBS感染传播途径与传播机制、母乳喂养相关感染影响因素及新生儿感染预防对策,为GBS阳性母亲母乳喂养提供依据。

Invasive group B streptococcus(GBS)disease is the leading cause of neonatal morbidity and mortality.Breast-milk is a potential source of neonatal late-onset GBS infection disease.Although the bioactive factors presenting in breast milk protects the neonate from infection potentially,breastfeeding by GBS positive mothers poses a risk of infection in the newborn.Breastfeeding by GBS positive mothers is controversial and there are no standard guidelines available.This article reviewed the epidemiology,transmission ways and pathogenesis of neonatal GBS late-onset infection disease,the breastfeeding related infection factors and prevention strategy of neonatal infection.It might provide a guide for GBS positive mothers’breastfeeding.