褪黑素提高机体免疫力:COVID-19辅助防治的探讨

Melatonin improves the body’s immunity:discussion on auxiliary prevention of COVID-19

褪黑素(melatonin,MT)是主要由动物松果腺分泌的一种胺类活性物质,在细胞内由线粒体合成,是体内自身合成的强抗氧化剂。褪黑素不仅可以调节生物节律,也能调节哺乳动物,特别是人的机体免疫功能。褪黑素可以抑制过度先天性免疫反应,降低炎症因子的产生和细胞、组织的氧化损伤,同时促进获得性免疫反应,在临床疾病防治中起到重要作用。文章主要综述了褪黑素对机体的免疫调节,降低埃博拉病毒、流感病毒和新型冠状病毒(COVID-19)感染临床症状的作用机制,为致死性病毒感染、特别是COVID-19感染的防治提供参考。

Melatonin(MT)is an amine active substance secreted mainly by the pineal gland of animals.It is synthesized by mitochondria in cells and is a strong antioxidant synthesized by the body itself.Melatonin can regulate not only the biological rhythm,but also the immune function of mammals,especially the human body.Melatonin suppresses excessive innate immune responses,reduces the production of inflammatory factors and oxidative damage to cells and tissues,and at the same time promotes the acquired immune response,which plays an important role in the prevention and treatment of clinical diseases.This article mainly reviews the mechanism of melatonin’s immune regulation on the body,reducing the clinical symptoms of Ebola virus,influenza virus and new coronavirus(COVID-19)infection,specially for the prevention and treatment of COVID-19 infection.