机械刺激对早期胚胎发育影响的研究进展

Research progress of mechanical stimulation on early embryo development in vitro

早期胚胎在体外发育过程中除需要化学营养物质外,物理因素(机械刺激)也发挥了重要作用。文章结合团队近年来在早期胚胎发育过程中基于微流控芯片技术在胚胎体外培养的研究,介绍了早期胚胎在体外培养过程中存在的问题、微流控技术在胚胎体外培养上的应用现状及进展、机械刺激对胚胎发育的影响因素。同时,对利用微流控技术手段提高早期胚胎体外发育率及质量的方法进行了展望。

Physical factors(mechanical stimulation)also play an important role in early embryos development in vitro except for chemical nutrients.In this paper,based on the results of the team application of microfluidics in embryo culture in vitro,which introduces the problems of early embryo culture in vitro,the application status and progress of microfluidic technology in embryo culture in vitro,and the influence factors of mechanical stimulation on early embryo development.Meanwhile,the method of improving the development rate and quality of early embryo in vitro using microfluidic technology is prospected.