尿液中16种稀土元素的电感耦合等离子体质谱同时测定法

Simultaneous determination of 16 rare earth elements in urine by inductively coupled plasma mass spectrometry

目的建立尿液中16种稀土元素(包括镧、铈、镨、钕、铕、钆、镝、钐、铽、钬、铒、铥、镱、镥、钪和钇)的电感耦合等离子体质谱同时测定法。方法尿液经1%硝酸直接稀释10倍后过滤,选择ICP-MS标准模式和标准加入法进样测定稀土元素的浓度。结果钪的线性范围为0.1~10μg/L,其余15种稀土元素的线性范围为0.05~10μg/L,所得回归方程的线性关系良好,r>0.999。方法的检出限为0.017~0.215μg/L,定量下限为0.052~0.718μg/L;加标回收率为92.1%~107.2%,RSD为0.2%~7.4%。结论该方法准确、快速、稳定且灵敏度高,适用于尿液中16种稀土元素的同时分析。

Objective To establish a test method for simultaneous determination of 16 rare earth elements in urine by inductively coupled plasma mass spectrometry,including lanthanum,cerium,praseodymium,neodymium,europium,gadolinium,dysprosium,samarium,terbium,holmium,erbium,thulium,ytterbium,lutetium,scandium and yttrium.Methods The urine was diluted 10 times with 1%nitric acid and then filtered,ICP-MS standard mode and standard addition method were used to determine the concentration of rare earth elements.Results The linear range of scandium was 0.1-10μg/L,and the linear range of the remaining 15 rare earth elements was 0.05-10μg/L,the linear relationship of regression equation was good,r>0.999.The limit of detection was 0.017-0.215μg/L,the limit of quantitations were 0.052-0.718μg/L.The recoveries were 92.1%-107.2%.The RSDs were 0.2%-7.4%.Conclusion This method is accurate,rapid,stable and highly sensitive and is applicable to the simultaneous analysis of 16 rare earth elements in urine.