孕早期全氟及多氟化合物暴露与5~6岁子代血脂异常的关系

Association between maternal perfluoroalkyl and polyfluoroalkyl substances exposure during early pregnancy and dyslipidemia in offspring aged 5-6 years

目的了解天津市孕妇孕早期血全氟及多氟化合物(PFASs)水平与子代5~6岁时血脂异常之间的关系,为孕期保健及有关部门环境卫生政策的制定提供参考。方法于2010—2012年采集并检测天津市孕妇孕早期血清中35种PFASs的浓度水平,在其子代5~6岁时对151名儿童进行空腹总胆固醇(TC)和三酰甘油(TG)检测。采用logistic回归模型分析孕早期PFASs水平与子代5~6岁时血脂异常的关系。结果35种PFASs中有16种检出率超过60%。151名儿童中有20名为血脂异常。多因素logistic回归结果显示,孕早期检出率超过60%的16种PFASs中,全氟壬酸(PFNA)(OR=4.63,95%CI:1.35~15.84)、全氟十一酸(PFUdA)(OR=4.71,95%CI:1.06~21.02)、全氟癸酸(PFDA)(OR=4.83,95%CI:1.34~17.44)、全氟十三酸(PFTrDA)(OR=27.90,95%CI:1.31~594.80)的浓度水平与子代5~6岁血脂异常发生存在正向关联(P<0.05);将上述4种PFASs物质浓度各自按三分位数分组后,与低浓度组相比,高浓度组儿童血脂异常发生的风险均增加(P<0.05)。结论孕早期PFASs暴露可能增加5~6岁子代血脂异常的风险。

Objective To understand the relationship between blood perfluoroalkyl and polyfluoroalkyl substances(PFASs)levels of pregnant women during the first-trimester and dyslipidemia risk in offspring aged 5-6 years in Tianjin,and to provide reference for the formulation of pregnant health care and environmental health policies.Methods Collected and detected the levels of 35 PFASs in the serum of pregnant women during the first-trimester.A total of 151 pregnant women and their offspring were recalled when offspring were 5-6 years old.All children were tested for fasting total cholesterol(TC)and triglyceride(TG).Logistic regression model was used to analyze the relationship between PFASs levels in early pregnancy and dyslipidemia risk in offspring aged 5-6 years.Results Among 35 PFASs,the detection rate of 16 PFASs exceeded 60%.We detected 20 children with dyslipidemia.The results of multivariable Logistic regression showed that among 16 PFASs with a detection rate of more than 60%,PFNA(OR=4.63,95%CI:1.35-15.84),PFUdA(OR=4.71,95%CI:1.06-21.02),PFDA(OR=4.83,95%CI:1.34-17.44),and PFTrDA(OR=27.90,95%CI:1.31-594.80)levels during the first-trimester were positively correlated with dyslipidemia risk in offspring aged 5-6 years(P<0.05).After grouping each above four PFASs levels into tertiles,the high concentration group showed an increased risk of dyslipidemia in children compared with the low concentration group(P<0.05).Conclusion Prenatal exposure to PFASs increased the risk of dyslipidemia in offspring aged 5-6 years.