摘要
基于分子生物学技术和细菌SOS修复反应建立的SOS/umu试验法,具有操作便利、检测敏感性高、测试费用低等优点,成为检测环境致突变物和致癌物的短期试验中应用最广泛的方法之一。笔者对基于细菌SOS反应的遗传毒性测试方法的设计原理、研究进展及其在水质遗传毒性监测的应用等方面做了系统综述,并对SOS/umu试验法的进一步推广提出了建议和展望。
SOS/umu test based on molecular biological technology and bacterial SOS repair reaction has the advantages of convenient operation,high sensitivity and low cost.It has become one of the most widely used methods in environmental mutagens and carcinogens short-term test.In this paper,the design principle,research progress and application of the test method based on bacterial SOS reaction in water genotoxicity monitoring were reviewed systematically,and the suggestions and prospects for further popularization of SOS/umu test were put forward also.
作者
许燕
郭小雅
逯南南
王明泉
赵清华
孙莉
孙韶华
贾瑞宝
XU Yan;GUO Xiao-ya;LU Nan-nan;WANG Ming-quan;ZHAO Qing-hua;SUN Li;SUN Shao-hua;JIA Rui-bao(Shandong Province City Water Supply and Drainage Water Quality Monitoring Center,Ji’nan,Shandong 250100,China;不详)
出处
《环境与健康杂志》
CAS
北大核心
2020年第3期277-282,共6页
Journal of Environment and Health
基金
国家科技重大专项(2017ZX07502003-06,2017ZX07501-003,2018ZX07502-001)
山东省泰山学者建设工程专项(ts201712084)
泉城“5150”引才倍增计划
山东省自然科学基金面上项目(ZR2017MC047)