盐酸氨溴索纤支镜灌洗治疗重症肺部感染的效果观察

Effect of Ambroxol Hydrochloride Bronchoscopy on Severe Pulmonary Infection

目的探究盐酸氨溴索纤支镜灌洗治疗重症肺部感染的效果。方法选取接受治疗的重症肺部感染患者102例为受试对象,根据非随机临床同期对照研究及患者自愿原则将其分为2组。其中对照组50例予以常规治疗,观察组52例在其基础上使用盐酸氨溴索纤支镜灌洗治疗。比较两组临床疗效,并记录两组患者治疗前及治疗14d后的肺泡灌洗液炎症因子水平与血气分析指标水平变化。结果经治疗,观察组总有效率为94.1%,显著高于对照组的80.4%(P<0.05);治疗14d后,两组患者血清CRP、IL-6、TNF-α水平及PaCO2较治疗前均有显著下降(P<0.05)且观察组下降幅度更大(P<0.05);治疗14d后,两组患儿PaO2及SaO2均较治疗前显著提升(P<0.05),且观察组上升幅度更大(P<0.05)。结论盐酸氨溴索纤支镜灌洗可明显改善重症肺部感染症状,调节患者血气分析指标,且能显著降低炎性因子水平。

Objective To investigate the effect of ambroxol hydrochloride bronchoscopy in the treatment of severe pulmonary infection.Methods 102 Patients with severe pulmonary infection who were treated in our hospital were enrolled in the study.They were divided into two groups according to the non-randomized clinical concurrent control study and the voluntary principle of patients.Among them,50 patients in the control group were treated with conventional therapy,and 52 patients in the observation group were treated with ambroxol hydrochloride bronchoscopy.The clinical efficacy of the two groups was compared,and the levels of inflammatory factors and blood gas analysis indicators of alveolar lavage fluid before and after treatment were recorded.Results After treatment,the total effective rate of the observation group was 94.1%,which was significantly higher than that of the control group(80.4%)(P<0.05).After treatment for 14 days,the levels of serum CRP,IL-6,TNF-αand PaCO2 in the two groups were significantly lower than those before treatment(P<0.05)and the decrease in the observation group was greater(P<0.05).After treatment for 14 days,PaO2 and SaO2 in both groups were significantly higher than those before treatment(P<0.05),and the increase in the observation group was greater(P<0.05).Conclusion Ambroxol hydrochloride bronchoscopy can significantly improve the symptoms of severe pulmonary infection,regulate blood gas analysis indicators,and significantly reduce the level of inflammatory factors.