摘要
Y染色体中性别决定区相关的高迁移率组框(SOX)转录因子家族成员参与了多种生物行为过程的调节。本文就该家族中的SOX9在相关心血管疾病中发挥的作用作一综述,分别介绍了SOX9生物学特征以及其在心脏生长发育、心脏纤维化、心肌肥大、瓣膜钙化、动脉粥样硬化中的影响,为今后预防和治疗相关心血管疾病提供一个可能的方向。
Members of the sex-determining region on the Y chromosome-related high mobility group box(SOX)transcription factor family participate in the regulation of various biological behavioral processes.This article describes the role of SOX9 in some related cardiovascular diseases,including in cardiac growth and development,heart fibrosis,myocardial hypertrophy,valve calcification,and atherosclerosis,and aims to provide a possible direction for the prevention and treatment of related cardiovascular diseases.
作者
崔胜宇
夏豪
CUI Shengyu;XIA Hao(Dept.of Cardiology,Renmin Hospital of Wuhan University,Cardiovascular Research Institute,Wuhan University,&Hubei Key Laboratory of Cardiology,Wuhan 430060,Hubei,China)
出处
《武汉大学学报（医学版）》
CAS
2020年第5期848-852,共5页
Medical Journal of Wuhan University
基金
国家自然科学基金面上项目(编号:81370283)
