摘要
心肌重构是指心脏为适应各种负荷增加,心脏在结构及功能上发生适应性代偿作用,负荷长期持续最终失代偿引起心力衰竭。蛋白质翻译后修饰(PTM),包括磷酸化、泛素化、糖基化等,在心肌重构中起着重要作用。在这篇综述中,我们总结了PTM在心血管疾病及心肌重构的发生发展中的作用。
Cardial remodeling refers to the adaptive compensation of heart in the structure and function,in order to adapt to the increase of various loads,and long-term sustained decompensation results in heart failure.Protein post-translational modification(PTM),including phosphorylation,ubiquitination,and glycosylation,plays an important role in myocardial remodeling.In this review,we summarize the role of PTM in the occurrence and development of cardiovascular disease and myocardial remodeling.
作者
黄荣
徐蔓
唐其柱
HUANG Rong;XU Man;TANG Qizhu(Dept.of Cardiology,Renmin Hospital of Wuhan University,Cardiovascular Research Institute of Wuhan University,&Hubei Key Laboratory of Cardiology,Wuhan 430060,Hubei,China)
出处
《武汉大学学报(医学版)》
CAS
2020年第5期844-847,共4页
Medical Journal of Wuhan University
基金
国家自然科学基金重点项目(编号:81530012)
国家重点研发计划资助项目(编号:2018YFC1311300)
关键词
蛋白质翻译后修饰
磷酸化
糖基化
心血管疾病
心肌重构
Protein Post-Translation Modification
Phosphorylation
Glycosylation
Cardiovascular Disease
Cardial Remodeling