蛋白质翻译后修饰与心肌重构的研究进展

Research progress of protein post-translation modification and cardial remodeling

心肌重构是指心脏为适应各种负荷增加,心脏在结构及功能上发生适应性代偿作用,负荷长期持续最终失代偿引起心力衰竭。蛋白质翻译后修饰(PTM),包括磷酸化、泛素化、糖基化等,在心肌重构中起着重要作用。在这篇综述中,我们总结了PTM在心血管疾病及心肌重构的发生发展中的作用。

Cardial remodeling refers to the adaptive compensation of heart in the structure and function,in order to adapt to the increase of various loads,and long-term sustained decompensation results in heart failure.Protein post-translational modification(PTM),including phosphorylation,ubiquitination,and glycosylation,plays an important role in myocardial remodeling.In this review,we summarize the role of PTM in the occurrence and development of cardiovascular disease and myocardial remodeling.