特定基因甲基化在动脉粥样硬化性心血管疾病中的研究进展

Progress in the study of specific gene methylation in atherosclerotic cardiovascular disease

动脉粥样硬化性心血管疾病(ASCVD)是威胁人类健康的主要疾病之一,其发生发展受到遗传因素和环境因素的共同调控,DNA的甲基化修饰在其中具有重要作用。特定基因启动子区不同水平的甲基化修饰会影响基因的功能,增加ASCVD的患病风险。目前ASCVD特定基因甲基化研究主要集中在与炎症反应、脂质代谢、巨噬细胞泡沫化及衰老相关的基因上。本文结合最新的表观基因组关联分析(EWAS)和临床研究进展,对特定基因甲基化修饰在ASCVD发生发展中的作用做出了系统的阐释。

Atherosclerotic cardiovascular disease(ASCVD) is one of the major diseases that threaten human health. Its development is regulated by genetic factors and environmental factors. DNA methylation modification plays an important role in it. Different levels of methylation modification in specific gene promoter regions affect gene function and increase the risk of ASCVD. Current ASCVD-specific gene methylation studies have focused on genes involved in inflammatory responses, lipid metabolism,macrophage foaming, and aging. In this paper, combined with the latest epigenome-wide association study(EWAS)and clinical research progress, the role of specific gene methylation modification in the development of ASCVD has been systematically explained.