基于定量CT对不同性别、年龄人群血尿酸与腰椎骨密度的相关性分析

Correlation analysis of serum uric acid and lumbar spine bone mineral density in different genders and age groups based on quantitative CT

目的:应用定量CT(QCT)测量腰椎骨密度(BMD),研究不同性别、年龄人群腰椎BMD和血尿酸(SUA)之间的相关性。方法:选取2018年7月-8月在本院健康体检中心的体检人群1622例,其中男923例,女699例,年龄40~93岁,平均(55.28±10.17)岁。询问研究对象既往史,测量其身高、体重,并计算体重指数(BMI)。空腹采集静脉血检测血尿酸,并将不同性别的研究对象根据血尿酸水平分别分成尿酸正常组和高尿酸组。采用QCT软件测量腰椎BMD,根据QCT骨质疏松诊断标准将研究对象分为骨量正常组、骨量减少组及骨质疏松组,分析不同性别中老年人腰椎BMD与血尿酸之间的相关性。结果:男性人群中高尿酸组的腰椎BMD水平稍高于尿酸正常组,差异无统计学意义(t=-0.697,P>0.05),女性人群中高尿酸组的腰椎BMD水平低于尿酸正常组,差异有统计学意义(t=6.830,P<0.01)。男性人群中,三组随骨量的减少,血尿酸水平呈下降趋势,其中骨质疏松组<骨量减少组<骨量正常组(P>0.05)。女性人群中,三组随骨量的减少,血尿酸水平呈上升趋势,其中骨质疏松组>骨量减少组>骨量正常组(P<0.01)。相关性分析结果显示,男性腰椎BMD与年龄呈负相关(r=-0.487,P<0.01),与血尿酸水平无明显相关性(r=0.041,P>0.05)。女性腰椎BMD与年龄、血尿酸均呈负相关(r=-0.750,-0.263,均P<0.01)。结论:本研究发现女性人群的高尿酸血症会导致腰椎BMD下降。血尿酸水平与中老年女性腰椎BMD呈负相关,未发现血尿酸与中老年男性腰椎BMD存在相关关系。

Objective:Quantitative CT(QCT)was used to measure lumbar spine bone mineral density(BMD)to study the correlation between lumbar spine BMD and serum uric acid(SUA)in different genders and age groups.Methods:A total of 1622 physical examinations were performed in our health check-up center from July to August 2018,including 923 males and 699 females,aged from 40 to 93 years,with an average age of(55.28±10.17)years.The subject’s past history,the height,weight,and the body mass index(BMI)were acquired.Venous blood on an empty stomach was collected to detect blood uric acid.The subjects of different genders were divided into two groups including uric acid normal group and high group according to blood uric acid level;QCT software was used to measure lumbar spine BMD according to QCT osteoporosis diagnostic criteria.The subjects were divided into normal bone mass group,bone mass reduction group and osteoporosis group.The correlation between lumbar spine BMD and blood uric acid was analyzed.Results:The BMD level of lumbar vertebrae in uric acid high group was slightly higher than that in uric acid normal group for male(t=-0.697,P>0.05).The BMD level of the lumbar spine in uric acid high group was lower than that in uric acid normal group for female with statistical significance(t=6.830,P<0.01).For male,the blood uric acid level decreased with the decrease of bone mass among the three groups:osteoporosis group<bone mass reduction group<normal bone mass group(P>0.05);For female,blood uric acid level of three groups showed an upward trend with the decreased bone mass:osteoporosis group>bone mass reduction group>normal bone mass group(P<0.01).Correlation analysis showed that male BMD was negatively correlated with age(r=-0.487,P<0.01).No significant correlation existed for BMD with blood uric acid level(r=0.041,P>0.05).BMD of female lumbar spine was negatively correlated with age and the level of serum uric acid(r values were-0.750 and-0.263,both P<0.01).Conclusion:Hyperuricemia in the female population can lead to a decrease in lumbar spine bone mineral density;blood uric acid level was negatively correlated with lumbar spine BMD in middle-aged and elderly women,and no correlation was found for lumbar spine BMD in middle-aged and elderly men.