羟苯磺酸钙辅助532 nm眼底激光对糖尿病视网膜病变患者黄斑厚度及视网膜新生血管荧光素渗漏面积的影响

Effect of Calcium Dobesilate Assisted 532 nm Fundus Laser on Macular Thickness and Retinal Neovascularization Fluorescein Leakage Area in Patients with Diabetes Retinopathy

目的探讨羟苯磺酸钙辅助532 nm眼底激光对糖尿病视网膜病变(DR)患者的影响。方法以2020年5月—2023年5月于我院门诊和住院治疗的150例DR患者为研究对象,按照随机数字表法将其分为对照组和观察组,各75例。对照组实施532 nm眼底激光治疗,观察组在对照且基础上加用羟苯磺酸钙治疗。比较两组视力水平、视网膜新生血管荧光素渗漏面积、黄斑厚度、生活质量、并发症发生情况。结果治疗后,观察组视网膜新生血管荧光素渗漏面积(2.78±0.55)mm^(2)小于对照组,黄斑厚度(305.12±38.46)μm薄于对照组,视力水平(0.75±0.21)及世界卫生组织生存质量测定量表中的环境领域评分(79.88±6.42)分、心理领域评分(80.66±6.97)分、社会关系领域评分(82.13±6.73)分、生理领域评分(79.84±6.63)分均高于对照组,组间差异有统计学意义(P<0.05)。两组并发症发生率比较,差异无统计学意义(P>0.05)。结论羟苯磺酸钙辅助532 nm眼底激光治疗,可明显缩减黄斑厚度,减小渗漏面积,有助于视力改善,且安全性高。

Objective To investigate the effect of calcium dobesilate assisted 532 nm fundus laser on patients with diabetes retinopathy(DR).Methods A total of 150 DR patients who received outpatient and inpatient treatment in our hospital from May 2020 to May 2023 were selected as the study subjects,they were randomly divided into a control group and an observation group,with 75 patients in each group,using a random number table method.The control group received 532 nm fundus laser treatment,while the observation group received additional calcium hydroxybenzenesulfonate.Compare the visual acuity level,retinal neovascularization fluorescein leakage area,macular thickness,quality of life,and complications between two groups.Results After treatment,the observation group had a smaller retinal neovascularization fluorescein leakage area(2.78±0.55)mm^(2)compared to the control group,a thinner macular thickness(305.12±38.46)μm,a higher visual acuity level(0.75±0.21),and a higher environmental score(79.88±6.42)points,psychological score(80.66±6.97)points,social relationship score(82.13±6.73)points,and physiological score(79.84±6.63)points in the World Health Organization Quality of Life-BREF Scale,and the differences between the groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of complications between the two groups(P>0.05).Conclusion Calcium hydroxybenzenesulfonate assisted 532 nm fundus laser treatment can significantly reduce macular thickness,decrease leakage area,help improve vision,and has high safety.