艾地苯醌口服治疗对老年帕金森病患者认知功能及睡眠质量的影响

The Effect of Oral Treatment with Idebenone on Cognitive Function and Sleep Quality in Elderly Parkinson's Disease Patients

目的探讨艾地苯醌口服治疗对老年帕金森病(PD)患者认知功能及睡眠质量的影响。方法选取我院2021年10月—2023年1月收治的80例PD患者为研究对象,按随机数字表法将其分为对照组和观察组,每组40例。对照组采用多巴丝肼片治疗,观察组在对照组基础上加用艾地苯醌治疗。两组持续治疗12个月。对比两组的神经细胞因子水平、氧化应激指标水平、认知功能、睡眠质量及不良反应发生情况。结果治疗后,两组脑源性神经营养因子、神经生长因子水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,观察组超氧化物歧化酶水平高于对照组,丙二醛、8-羟基脱氧鸟苷酸水平均低于对照组,组间差异有统计学意义(P<0.05);治疗后,观察组蒙特利尔认知评估量表评分高于对照组,匹兹堡睡眠质量指数量表评分低于对照组,组间差异有统计学意义(P<0.05);两组恶心、头晕、胀气及腹泻情况对比,组间差异无统计学意义(P>0.05)。结论艾地苯醌口服治疗能够调节老年PD患者的神经细胞因子水平,改善氧化应激指标、认知功能及睡眠质量,且不良反应少。

Objective To explore the effects of oral treatment with idebenone on cognitive function and sleep quality in elderly patients with Parkinson's disease(PD).Methods Selecting 80 PD patients admitted to our hospital from October 2021 to January 2023 as the research subjects,they were divided into a control group and an observation group using a random number table method,with 40 cases in each group.The control group was treated with levodopa and benserazide hydrochloride tablets,while the observation group was treated with an additional dose of idebenone in addition to the control group.Two groups of continuous treatment for 12 months.Compare the neurocytokines,oxidative stress indicators,cognitive function,sleep quality,and adverse reactions between the two groups.Results After treatment,the levels of brain-derived neurotrophic factor and nerve growth factor in both groups were higher than before treatment,and the observation group was higher than the control group,the differences was statistically significant(P<0.05);after treatment,the superoxide dimutase level in the observation group was higher than that in the control group,while the malondialdehyde,8-hydroxydeoxyguanylic acid levels were lower than those in the control group,the differences between groups were statistically significant(P<0.05);after treatment,the Montreal Cognitive Assessment Scale score of the observation group was higher than that of the control group,and the Pittsburgh Sleep Quality Index Scale score was lower than that of the control group,the differences between groups were statistically significant(P<0.05);comparison of nausea,dizziness,bloating,and diarrhea between two groups,there was no statistically significant differences between groups(P>0.05).Conclusion Oral treatment with idebenone can regulate neurocytokines,improve oxidative stress indicators,cognitive function,and sleep quality in elderly PD patients,and with fewer adverse reactions.