贝伐珠单抗联合GP化疗对非小细胞肺癌患者肿瘤标志物及免疫功能的影响

Effects of Bevacizumab Combined with GP Chemotherapy on Tumor Markers and Immune Function in Non-Small Cell Lung Cancer Patients

目的探讨贝伐珠单抗联合吉西他滨+顺铂(GP)化疗对非小细胞肺癌(NSCLC)患者的影响。方法回顾性分析2021年3月—2023年3月寿光市人民医院收治的82例NSCLC患者的临床资料,按不同治疗方案将其分为GP组(n=40)和联合组(n=42),GP组采用GP化疗方案,联合组采用贝伐珠单抗联合GP化疗方案。比较两组的疾病控制率、肿瘤标志物、免疫功能及毒副反应。结果联合组疾病控制率为76.19%,高于GP组的57.50%,差异有统计学意义(P<0.05);治疗后,两组癌胚抗原、血清糖类抗原125水平均低于治疗前,且联合组低于GP组,差异有统计学意义(P<0.05);治疗后,联合组免疫球蛋白A、M、G水平均高于GP组,组间差异有统计学意义(P<0.05);两组血小板减少、胃肠道反应、白细胞下降、肝肾受损发生率对比,组间差异无统计学意义(P>0.05)。结论NSCLC患者经贝伐珠单抗联合GP化疗,可有效缓解病情,改善机体免疫功能,且安全性良好。

Objective To explore the effect of bevacizumab combined with gemcitabine+cisplatin(GP)chemotherapy on non-small cell lung cancer(NSCLC)patients.Methods Clinical data of eighty-two patients with NSCLC admitted to Shouguang People's Hospital from March 2021 to March 2023 were retrospectively analyzed,and they were divided into a GP group(n=40)and a combined group(n=42)according to different treatment regimens.The GP group received GP chemotherapy and the combined group received bevacizumab combined GP chemotherapy.The disease control rate,tumor markers,immune function and toxic and side effects of the two groups were compared.Results The disease control rate of the combined group was 76.19%,higher than 57.50%of the GP group,the difference was statistically significant(P<0.05);after treatment,the levels of carcinoembryonic antigen and serum carbohydrate antigen 125 in 2 groups were lower than before treatment,and the combined group was lower than the GP group,the differences were statistically significant(P<0.05);after treatment,the levels of immunoglobulin A,M and G in the combination group were higher than those in the GP group,the differences between groups were statistically significant(P<0.05);there was no significant difference in the incidence of thrombocytopenia,gastrointestinal reaction,leukopenia and liver and kidney damage between the two groups.Conclusion NSCLC patients treated with bevacizumab combined with GP chemotherapy can effectively alleviate the condition,improve immune function,and have relatively mild toxic side effects.