氨溴索与利奈唑胺联合治疗对老年重症肺炎患者血气分析及肺部炎症反应的影响

Effect of Combined Treatment with Ambroxol and Linezolid on Blood Gas Analysis and Pulmonary Inflammatory Response in Elderly Patients with Severe Pneumonia

目的探讨氨溴索与利奈唑胺联合治疗老年重症肺炎的疗效。方法回顾性分析2021年3月—2023年4月该院收治的80例老年重症肺炎患者的临床资料,按治疗方法的不同将其分为对照组和观察组,各40例。对照组予以利奈唑胺单独治疗,观察组在对照组基础上加用氨溴索治疗,两组均持续治疗2周。对比两组的血气分析指标、炎症反应、临床疗效及不良反应发生情况。结果治疗后,观察组动脉血氧饱和度、动脉血氧分压水平均高于对照组,动脉血二氧化碳分压水平低于对照组,组间差异有统计学意义(P<0.05)。治疗后,观察组白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α水平均低于对照组,组间差异有统计学意义(P<0.05)。观察组治疗总有效率为95.00%,高于对照组的77.50%,差异有统计学意义(P<0.05)。两组不良反应发生率相比,差异无统计学意义(P>0.05)。结论氨溴索与利奈唑胺联合应用于老年重症肺炎患者中的疗效显著,可有效改善血气分析指标水平,减轻肺部炎症反应,且应用安全性较好。

Objective To explore the therapeutic effect of the combination therapy of ambroxol and linezolid in elderly patients with severe pneumonia.Methods A retrospective analysis was conducted on the clinical data of eighty elderly patients with severe pneumonia admitted to the hospital from March 2021 to April 2023.They were divided into a control group and an observation group according to different treatment methods,with 40 cases in each group.The control group was treated with linezolid alone,while the observation group was treated with ambroxol in addition to the control group.Both groups were treated continuously for 2 weeks.Compare the blood gas analysis indicators,inflammatory response,clinical efficacy,and adverse reactions between two groups.Results After treatment,the arterial oxygen saturation and arterial oxygen partial pressure levels in the observation group were higher than those in the control group,while the arterial carbon dioxide partial pressure levels were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the average levels of interleukin-6,interleukin-8,and tumor necrosis factor-αin the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).The total effective rate of the observation group was 95.00%,which was higher than the control group's 77.50%,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combined use of ambroxol and linezolid in elderly patients with severe pneumonia has significant therapeutic effects,can effectively improve the level of blood gas analysis indicators,alleviate pulmonary inflammatory reactions,and is safe to use.