皮下注射低分子肝素钙联合口服阿司匹林治疗妊娠期易栓症的效果

Effect of Subcutaneous Injection of Low Molecular Weight Heparin Calcium Combined with Oral Aspirin in the Treatment of Embolism in Pregnancy

目的探讨皮下注射低分子肝素钙联合口服阿司匹林治疗妊娠期易栓症的效果。方法选择2021年11月—2023年1月我院收治的60例妊娠期易栓症患者为研究对象,按随机数字表法将患者分为对照组和观察组,各30例。对照组采用皮下注射低分子肝素钙治疗,观察组在对照组基础上联合口服阿司匹林治疗。比较两组的血液流变学、凝血功能、妊娠结局及不良反应发生率。结果治疗前、后,两组凝血酶原时间、活化部分凝血活酶时间、血小板水平比较,组间差异均无统计学意义(P>0.05)。治疗后,观察组血浆黏度为(1.31±0.20)mPa/s、全血低切黏度为(9.63±1.31)mPa/s、全血高切黏度为(4.03±0.45)mPa/s,均低于对照组的(1.64±0.23)mPa/s、(11.12±1.54)mPa/s、(4.88±0.52)mPa/s,组间差异有统计学意义(P<0.05)。治疗后,观察组妊娠结局优于对照组,差异有统计学意义(P<0.05)。两组药物不良反应发生率比较,差异无统计学意义(P>0.05)。结论皮下注射低分子肝素钙联合口服阿司匹林治疗妊娠期易栓症,可有效调节患者的血液流变学指标,改善妊娠结局,提高活产率,不会对患者的凝血功能造成不良影响,同时不良反应未明显增加,具有一定的安全性。

Objective To investigate the effect of subcutaneous injection of low molecular weight heparin calcium combined with oral aspirin in the treatment of embolism in pregnancy.Methods A total of 60 patients with embolism in pregnancy admitted to our hospital from November 2021 to January 2023 were selected as the research objects,and were divided into a control group and an observation group according to random number table method,with 30 cases in each group.The control group was treated with subcutaneous injection of low molecular weight heparin calcium,and the observation group was treated with aspirin on the basis of control group.Hemorheology,coagulation function,pregnancy outcome and incidence of adverse reactions were compared between the two groups.Results Before and after treatment,comparison of two groups of prothrombin time,activated partial thromboplastin time,and platelet levels,there were no statistically significant differences between groups(P>0.05).After treatment,the plasma viscosity of the observation group was(1.31±0.20)mPa/s,the low viscosity of whole blood was(9.63±1.31)mPa/s,and the high viscosity of whole blood was(4.03±0.45)mPa/s,which was lower than(1.64±0.23)mPa/s,(11.12±1.54)mPa/s and(4.88±0.52)mPa/s in the control group,the differences between groups was statistically significant(P<0.05).After treatment,the pregnancy outcome of the observation group was better than that of the control group,the difference was statistically significant(P>0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups(P>0.05).Conclusion Subcutaneous injection of low molecular weight heparin calcium combined with oral as pirin in the treatment of embolism in pregnancy can effectively regulate the hemorheology indexes of the patients,improve the pregnancy outcome,and increase the live birth rate.It will not cause adverse effects on the coagulation function of the patients,and the adverse reactions are not significantly increased,which has a certain safety.