负压创面治疗技术配合削痂植皮术治疗深度烧伤的临床效果及安全性分析

Clinical Efficacy and Safety Analysis of Negative Pressure Wound Treatment Technology Combined with Scab Removal and Skin Grafting for the Treatment of Deep Burns

目的探讨负压创面技术联合削痂植皮术治疗深度烧伤患者的临床效果及安全性。方法选择2020年4月—2023年1月青岛市城阳区人民医院收治的70例深度烧伤患者为研究对象,按随机数字表法将其分为对照组与观察组,各35例。对照组采用削痂植皮术治疗,观察组在对照组基础上联合负压创面技术治疗,两组均连续治疗7 d。比较两组的创面愈合、疼痛程度、血清炎性因子及并发症发生情况。结果观察组创面愈合、肉芽生长时间均短于对照组,换药频次少于对照组,组间差异有统计学意义(P<0.05);治疗前,两组疼痛程度、血清炎性因子比较,组间差异无统计学意义(P<0.05);治疗后,观察组疼痛视觉模拟评分为(3.11±0.62)分,低于对照组的(5.21±0.54)分,差异有统计学意义(P<0.05);观察组肿瘤坏死因子-α、白细胞介素-6、C反应蛋白、白细胞计数水平均低于对照组,组间差异有统计学意义(P<0.05);观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论负压创面技术与削痂植皮术共同治疗浓度烧伤患者的效果更佳,可加快深度烧伤患者创面愈合速度,减轻其疼痛程度,降低炎症因子水平,且并发症较少,安全可靠。

Objective To explore the clinical efficacy and safety of negative pressure wound technology combined with scab removal and skin grafting in the treatment of deep burn patients.Methods Seventy patients with deep burn treated in Chengyang District People's Hospital of Qingdao from April 2020 to January 2023 were selected as the study objects,and were divided into a control group and an observation group according to random number table method,with 35 cases in each group.The control group was treated with scab grafting,and the observation group was treated with negative pressure wound technology on the basis of the control group.Both groups were treated continuously for 7 days.Wound healing,pain degree,serum inflammatory factors and complications were compared between the two groups.Results The time of wound healing and granulation growth in the observation group was shorter than that in the control group,and the dressing change frequency was less than that in the control group,with statistical significance(P<0.05);before treatment,there were no significant differences in pain degree and serum inflammatory factors between the two groups(P<0.05);after treatment,the Visual Analogue Score of the observation group was(3.11±0.62)points,which was lower than(5.21±0.54)points of the control group,and the difference was statistically significant(P<0.05);the levels of tumor necrosis factor-α,interleukin-6,C-reactive protein and white blood cell count in observation group were lower than those in the control group,with statistical significance(P<0.05);the incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion The combined treatment of negative pressure wound technology and scab removal and skin grafting is more effective in the treatment of patients with deep burns,which can accelerate the healing speed of deep burn wounds,reduce the pain degree,reduce the level of inflammatory factors,and have fewer complications,and is safe and reliable.