重组人脑利钠肽与硝普钠联合治疗急性心力衰竭的临床疗效及对患者心功能的影响

Clinical Efficacy of Recombinant Human Brain Natriuretic Peptide Combined with Sodium Nitroprusside in the Treatment of Acute Heart Failure and Its Influence on Cardiac Function

目的探究重组人脑利钠肽与硝普钠在治疗急性心力衰竭患者中的应用效果。方法选取2020年1月—2023年6月阳谷县人民医院收治的急性心力衰竭患者为研究对象,按随机数字表法将其分为对照组(n=63)与观察组(n=63)。对照组采用硝普钠治疗,观察组采用重组人脑利钠肽与硝普钠联合治疗,比较两组的临床疗效、心功能、炎症因子水平及不良反应。结果观察组治疗总有效率为90.48%,高于对照组的73.02%,治疗后,观察组左心室射血分数水平高于对照组,心率、血压均低于对照组,超敏C反应蛋白、白细胞介素-6、白细胞介素-8水平均低于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论重组人脑利钠肽与硝普钠联合治疗急性心力衰竭患者的效果明显,可有效改善其心功能,下调炎症因子水平,且安全性较佳。

Objective To explore the application effect of recombinant human brain natriuretic peptide and sodium nitroprusside in the treatment of acute heart failure.Methods Patients with acute heart failure admitted to Yanggu County People's Hospital from January 2020 to June 2023 were selected as the research objects,and were divided into a control group(n=63)and an observation group(n=63)according to random number table method.The control group was treated with sodium nitroprusside,and the observation group was treated with recombinant human brain natriuretic peptide and sodium nitroprusside.The clinical efficacy,cardiac function,levels of inflammatory factors and adverse reactions of the two groups were compared.Results The total effective rate of the observation group was 90.48%higher than 73.02%of the control group,after treatment,the left ventricular ejection fraction of the observation group was higher than that of the control group,the heart rate and blood pressure were lower than those of the control group,and the levels of hypersensitive C-reactive protein,interleukin-6 and interleukin-8 were lower than those of the control group,with statistical significance(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Recombinant human brain natriuretic peptide combined with sodium nitroprusside is effective in the treatment of acute heart failure patients,which can effectively improve their heart function,reduce the level of inflammatory factors,and has good safety.