AMH评估腹腔镜下卵巢巧克力囊肿剥除术后卵巢储备功能的临床意义

Clinical significance of AMH in evaluating ovarian reserve function after laparoscopic chocolate cyst removal

目的探讨抗苗勒氏管激素(AMH)在评估卵巢巧克力囊肿剥除术后患者卵巢储备功能的临床意义。方法选取2016年10月1日~2018年12月31日在我院行腹腔镜下巧克力囊肿剥除术的患者共50例,分为单侧组跟双侧组,检测其术前、术后1个月、3个月和6个月的AMH水平及血清内分泌激素FSH、LH和E2值,选择同期健康妇女25例作为对照组。结果术前不论单侧巧囊组还是双侧组与对照组比较,其各项指标均无统计学意义(P>0.05);单侧组术后AMH、E2及LH水平明显低于术前,差别有统计学意义(P<0.05),而FSH水平与治疗前相比无明显变化,差别无统计学意义(P>0.05)。双侧组术前术后比较其各项指标均无统计学意义(P>0.05),双侧组患者术后同时期其AMH水平、FSH、LH、E2值与单侧组相比,其差别无统计学意义(P>0.05)。结论腹腔镜下卵巢囊肿剥除术能造成一定程度的卵泡破坏,进一步降低卵巢的储备功能,而AMH作为近年来发现的评估卵巢功能变化的科学性较强的指标,相对于FSH而言具有一定的优越性。

Obective To investigate the clinical significance of Anti-Müllerian hormone(AMH)in evaluating ovarian reserve function in patients with ovarian chocolate cyst after removal of ovarian cyst.Methods A total of 50 cases of laparoscopic chocolate cyst removal in our hospital from October 1,2016 to December 31,2018 were selected,They were divided into unilateral group and bilateral group.AMH levels and serum endocrine hormones FSH,LH and E2 were measured before operation,1 month,3 months and 6 months after operation.25 healthy women in the same period were selected as control group.Results There was no significant difference in each index between unilateral capsule group and bilateral capsule group before operation and control group(P>0.05);The levels of AMH,E2 and LH in unilateral group were significantly lower than those before operation(P<0.05),while the levels of FSH had no significant change compared with those before treatment(P>0.05).The AMH,FSH,LH and E2 levels in bilateral group had no significant change compared with those before treatment(P>0.05).There was no significant difference in AMH,FSH,LH and E2 between bilateral group and unilateral group at the same time after operation(P>0.05).Conclusion Laparoscopic ovarian cystectomy can cause a certain degree of follicular destruction and further reduce ovarian reserve function.While AMH,as a scientific index to evaluate ovarian function changes found in recent years,has certain advantages over FSH.