端粒在生命早期不良环境和代谢性疾病关系中的作用

Role of telomeres in the relationship between early life adverse environments and metabolic diseases

大量流行病学和动物实验研究显示,除了生活方式和基因遗传外,生命早期不良因素暴露可能通过对胎儿端粒长度的影响,进而增加其成年后代谢性疾病的发生风险。然而早期不良因素暴露使代谢性疾病风险增加的机制尚不清楚。端粒生物学信息探索可能为预测生命早期不良环境暴露及生后健康问题提供新的途径。

Numerous epidemiological and animal experimental studies have shown that in addition to lifestyle and genetic inheritance,exposure to adverse factors in early life may increase the risk of metabolic diseases in adult offspring by affecting fetal telomere length.However,the mechanism by which early exposure to adverse factors increases the risk of metabolic diseases is still unclear.Exploring telomere biological information may provide new avenues for predicting adverse environmental exposure in early life and postnatal health issues.