儿童早期发育的表观遗传运动调控机制的认识进展

Advances in understanding epigenetic motor regulation mechanisms in early childhood development

儿童早期发育的健康质量与儿童日常生活中的膳食均衡和积极的身体活动密切相连,而随着生命科学研究的进展,人们对这一行动的科学认识越来越深刻。为此,在儿童膳食均衡的前提下,本文阐述了身体运动通过对机体表观遗传修饰的影响,有序进行下游功能基因的调控,发挥机体内细胞通讯和组织通讯稳态的支撑作用,从而保障儿童机体的良好发育。其中,通过对运动表观遗传学机制(包括DNA甲基化、组蛋白修饰、非组蛋白修饰、表观遗传修饰阅读器、运动的乳酸代谢和乳酸化修饰等)研究进展的介绍,系统地明确了儿童进行科学身体活动的分子基础。

The health quality of early childhood development is closely related to the balanced diet and active physical activity in children's daily life.With the progress of life science research,the scientific comprehension of this interrelation becomes increasingly profound.Therefore,under the premise of a nutritionally balanced diet for children,this paper describes the influence of body movement on the epigenetic modification of the body.The orderly regulation of downstream functional genes plays a supporting role in the homeostasis of cell communication and tissue communication in the body,so as to ensure the good development of children's bodies.Among them,the mechanism of exercise epigenetics,including DNA methylation,histone modification,non-histone modification,epigenetic modification reader,exercise lactate metabolism and lactoacylation modification and other research progress are introduced,and the molecular basis of children's scientific physical activity is systematically clarified.