维生素D受体基因多态性及维生素D水平与神经发育障碍关系的研究进展

Research advances on the correlation of gene polymorphisms of vitamin D receptor and vitamin D level with neurodevelopmental disorders in children

维生素D及其受体在人体不同区域有广泛表达,后者介导活性维生素D的所有分子功能,其基因多态性已被证实与多种发育障碍类疾病易感性相关。现对维生素D受体基因多态性及维生素D水平与神经发育障碍关系的研究进行综述,以期为患儿临床早期预防、干预和治疗提供理论参考。

Vitamin D and its receptors(VDR)are widely expressed in various regions of human body.VDR mediates all molecular effects of active vitamin D,and its gene polymorphisms have been linked to a variety of neurodevelopmental disease.This article reviews the association of vitamin D and VDR gene polymorphisms with childhood neurodevelopmental disorders,providing theoretical reference for early prevention,intervention and treatment in children.