支气管肺发育不良早产儿神经发育研究

Research progress in the neurodevelopment of preterm infants with bronchopulmonary dysplasia

支气管肺发育不良(BPD)是一种由肺发育不良引起的炎症性疾病,并与远期神经发育不良密切相关。BPD早产儿在运动、认知、神经感觉和行为等方面也存在发育障碍,但BPD引起早产儿神经发育不良的机制尚不明确。本文就BPD对早产儿神经发育的影响及潜在机制,包括高氧暴露、炎症、糖皮质激素、营养等进行综述,以期为BPD新型呼吸支持技术及相关神经发育障碍治疗提供参考。

Bronchopulmonary dysplasia(BPD)is an inflammatory disease caused by dysplasia of the lungs,and is closely related to long-term neurological dysplasia.Premature infants with BPD have developmental impairments in motor,cognitive,neurosensory and behavioral areas,but the mechanism by which BPD causes neurodevelopmental dysplasia in preterm infants remains unclear.This article reviews the effect of BPD on the neurodevelopment of preterm infants and its potential mechanism,including hyperoxia exposure,inflammation,glucocorticoids and nutrition,in order to provide reference for the new respiratory support technology and related neurodevelopment treatment of BPD.