肠道微生物及其代谢产物与孤独症谱系障碍的研究进展

Research progress on intestinal microbes and their metabolites and autism spectrum disorder

目前,孤独症谱系障碍(ASD)病因和表现的潜在机制仍然知之甚少。越来越多的研究表明,肠道微生物及其代谢产物(如短链脂肪酸、γ-氨基丁酸等)的改变可能与ASD的发病有关。因此,本文将ASD儿童肠道微生物和代谢物的变化及机制的相关研究进行综述,分析ASD儿童和健康儿童之间可能存在的肠道微生物与代谢产物的差异及联系,以探讨肠道微生物及其代谢物的变化对ASD患儿的影响,为ASD的诊断和治疗提供一些新的思路。

Currently,the underlying mechanisms of etiology and manifestations of autism spectrum disorder(ASD)are still poorly understood.More and more studies have shown that changes in intestinal microbes and their metabolites(such as short-chain fatty acids,γ-aminobutyric acid,etc.)may be related to the pathogenesis of ASD.Therefore,this paper reviews the studies related to the changes and mechanisms of gut microbes and metabolites in ASD children,and analyzes the possible differences and associations of gut microbes and metabolites between ASD children and healthy children,in order to explore the influence of changes in intestinal microbes and their metabolites on children ASD,and to provide some new ideas for the diagnosis and treatment of ASD.