丁苯酞联合抗血小板聚集药物治疗老年急性脑梗死的效果

Effect of combined application of butylphthalide and antiplatelet aggregation drugs on elderly patients with acute cerebral infarction

目的分析丁苯酞联合抗血小板聚集药物治疗老年急性脑梗死的临床价值。方法选取2018年2月至2019年2月在河南科技大学第一附属医院接受治疗的急性脑梗死老年患者50例为研究对象,根据患者入院治疗先后顺序将其分为对照组与研究组,每组25例。对照组只应用抗血小板聚集药物,研究组在对照组治疗基础上联合应用丁苯酞治疗。对比分析接受治疗前后两组患者实验室相关指标情况以及治疗后患者神经功能恢复情况。结果接受治疗后两组患者IL-6、MDA、TNF-α水平以及NIHSS平均较治疗前均明显降低,但研究组降低幅度明显大于对照组(P<0.05)。结论联合应用抗血小板聚集药物、丁苯酞对急性脑梗死老年患者实施治疗,可有效降低炎症因子水平、血清MDA浓度,促进患者神经功能恢复,值得在临床治疗中推广应用。

Objective To analyze the value of antiplatelet aggregation drugs combined with butylphthalide in the treatment of acute cerebral infarction in the elderly.Methods Fifty elderly patients with acute cerebral infarction who were treated in the First Affiliated Hospital of Henan University of Science and Technology from February 20 to February 2019 were enrolled in the study.According to the order of admission,the patients were divided into the control group and the study group,with 25 cases in each group.The control group only used antiplatelet aggregation drugs,and the study group was treated with butylphthalide on the basis of the control group.The laboratory related indicators before and after the treatment and neurological recovery after treatment was compared.Results The levels of IL-6,MDA,TNF-αand NIHSS in the two groups were significantly lower than those before treatment,but the reduction in the study group was significantly greater than that in the control group(P<0.05).Conclusions Combined application of antiplatelet aggregation drugs and butylphthalide in the treatment of elderly patients with acute cerebral infarction can effectively reduce the level of inflammatory factors,serum MDA concentration,and promote the recovery of neurological function in patients.It is worthy of popularization and application in clinical treatment.