生长抑制因子3在甲状腺癌组织中的表达及其与临床病理的相关性

Expression of growth inhibitory factor 3 in thyroid carcinoma and its correlation with clinicopathology

目的探讨生长抑制因子3(ING3)在甲状腺癌组织中的表达及其与临床病理的相关性。方法选取2015年1月至2019年7月广州第十二人民医院收治的42例甲状腺癌患者,其中乳头状癌32例,滤泡状癌7例,未分化癌3例。收集35例甲状腺良性病变标本;再取经病理证实无癌症侵犯的癌旁组织21例。将所有标本进行免疫组织化学染色,观察染色情况;根据显色状态判断ING3阳性表达及高低程度表达情况。结果甲状腺癌组织中ING3阳性表达率显著高于良性病变及癌旁组织(P<0.05)。良性病变与癌旁组织中ING3阳性表达比较差异未见统计学意义(P>0.05)。乳头状癌、滤泡状癌及未分化癌组织中ING3阳性表达比较差异未见统计学意义(P>0.05)。甲状腺癌组织中ING3总低表达率为74.67%(29/42),高表达率为25.33%(13/42)。甲状腺癌患者淋巴结转移及肿瘤复发或远处转移组织中ING3低表达率显著高于高表达率(P>0.05)。结论ING3在甲状腺癌组织中阳性表达率相对于其他组织较高,可作为甲状腺癌辅助诊断指标,且淋巴结转移、肿瘤复发与ING3低表达有关,可有效评估患者病理状况。

Objective To investigate the expression of growth inhibitory factor 3(ING3)in thyroid carcinoma and its correlation with clinicopathology.Methods A total of 42 patients with thyroid cancer admitted to our hospital from January to September 2019 were enrolled,including 32 cases with papillary carcinoma,7 cases with follicular carcinoma,and 3 cases with undifferentiated carcinoma.Thirty-five specimens of benign thyroid lesions were collected;21 cases of paracancerous tissues confirmed by pathology without cancer invasion were taken.All specimens were subjected to immunohistochemical staining to observe the staining condition;the positive expression of ING3 and the expression of high and low levels were judged according to the coloration state.Results The positive expression rate of ING3 in thyroid carcinoma tissues was significantly higher than that in benign lesions and adjacent tissues(P<0.05).There was no significant difference in the positive expression of ING3 between benign lesions and adjacent tissues(P>0.05).There was no significant difference in the expression of ING3 among papillary carcinoma,follicular carcinoma and undifferentiated carcinoma(P>0.05).The total low expression rate of ING3 in thyroid carcinoma tissue was 74.67%(29/42),and the high expression rate was 25.33%(13/42).The low expression rate of ING3 in lymph node metastasis and tumor recurrence or distant metastasis of thyroid cancer patients was significantly higher than that of high expression(P>0.05).Conclusions The positive expression rate of ING3 in thyroid cancer tissues is higher than that in other tissues.It can be used as an auxiliary diagnostic index for thyroid cancer,and lymph node metastasis and tumor recurrence are related to low expression of ING3,which can effectively evaluate the pathological condition of patients.