基于近红外光谱的脑血氧无创监测系统研究

Research on non-invasive monitoring system based on cerebralblood oxygen on near infrared spectroscopy

目前临床使用的脑血氧无创监测设备大多为双波长,由于黑色素的吸收会导致测量结果出现偏差,因此需要对测量结果进行修正。为此本文基于近红外光谱无创监测脑血氧的基本原理,针对现有脑血氧无创监测设备的不足,考虑前额叶的光学特性,研制了一种四波长探测光源(700、760、805、850 nm)以及双路光电检测器的脑血氧无创监测传感装置,并建立了光谱吸光度的数学模型,在此基础上构建了新型的脑血氧无创监测系统,实现了可抑制皮肤黑色素成分干扰的脑血氧信息无创测量。最后通过对Valsalva运动以及空载的对照实验进行秩和分析,初步验证了本系统的有效性。

At present,most of the non-invasive monitoring equipment for cerebral blood oxygen in clinical use is dual-wavelength.Because the absorption of melanin will cause deviations in the measurement results,the measurement results need to be corrected.For this reason,based on the basic principle of non-invasive monitoring of cerebral blood oxygen by near infrared spectroscopy,in view of the shortcomings of existing non-invasive monitoring equipment for cerebral blood oxygen,considering the optical characteristics of the prefrontal lobe,a four-wavelength detection light source(700,760,805,850 nm)and a dual-channel photoelectric detector for non-invasive monitoring of cerebral blood oxygen,and a mathematical model of spectral absorbance is established.On this basis,a new type of non-invasive monitoring system for cerebral blood oxygen is constructed,which can inhibit the interference of skin melanin components to non-invasively measure the cerebral blood oxygen information.Finally,through the rank sum analysis of the Valsalva exercise and no-load control experiments,the effectiveness of the system is preliminarily verified.